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The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles

DC Field Value Language
dc.contributor.author정진영-
dc.contributor.author서활-
dc.contributor.author오상호-
dc.contributor.author이주희-
dc.contributor.author정기양-
dc.date.accessioned2014-12-18T09:51:00Z-
dc.date.available2014-12-18T09:51:00Z-
dc.date.issued2013-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88946-
dc.description.abstractThe degradation of structural collagen contributes to the characteristic appearance of wrinkles. The anti-wrinkle effects of a variety of substances have been studied, but the potential anti-wrinkle effects of topical applications of collagen for periorbital wrinkles have not been investigated. To evaluate the effects of topical application of succinylated atelocollagen on periorbital wrinkles and to compare the results of treatment with adenosine, a clinical study on Korean participants was carried out. Each participant’s right or left periorbital area was treated with either a solution containing succinylated atelocollagen and adenosine or a solution containing only succinylated atelocollagen for two months. A placebo solution was applied to the opposite periorbital area of each patient’s face for two months. Based on objective and subjective measurements of clinical improvement, the assessment scores for treated sites were statistically significantly higher than scores for placebo sites after two months of treatment. Analysis of silicone casts of periorbital wrinkles demonstrated partial effects of succinylated atelocollagen on periorbital wrinkles. However, we did not observe any effects of adenosine on periorbital wrinkles. Succinylated atelocollagen may be an effective treatment option for periorbital wrinkles, but further studies including a longer treatment period and larger subject group are needed to verify these results.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJournal of Cosmetics, Dermatological Sciences and Applications-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorDong Jin Ryu-
dc.contributor.googleauthorJin Young Jung-
dc.contributor.googleauthorKee Yang Chung-
dc.contributor.googleauthorHwal Suh-
dc.contributor.googleauthorSang Ho Oh-
dc.contributor.googleauthorJu Hee Lee-
dc.identifier.doi10.4236/jcdsa.2013.33036-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01924-
dc.contributor.localIdA02370-
dc.contributor.localIdA03582-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ01355-
dc.identifier.pmidAdenosine ; Succinylated Atelocollagen ; Periorbital Wrinkles-
dc.subject.keywordAdenosine-
dc.subject.keywordSuccinylated Atelocollagen-
dc.subject.keywordPeriorbital Wrinkles-
dc.contributor.alternativeNameJung, Jin Young-
dc.contributor.alternativeNameSuh, Hwal-
dc.contributor.alternativeNameOh, Sang Ho-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.alternativeNameChung, Kee Yang-
dc.contributor.affiliatedAuthorSuh, Hwal-
dc.contributor.affiliatedAuthorOh, Sang Ho-
dc.contributor.affiliatedAuthorChung, Kee Yang-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.rights.accessRightsfree-
dc.citation.volume3-
dc.citation.number3-
dc.citation.startPage234-
dc.citation.endPage241-
dc.identifier.bibliographicCitationJournal of Cosmetics, Dermatological Sciences and Applications, Vol.3(3) : 234-241, 2013-
dc.identifier.rimsid33694-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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