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MicroRNAs as novel regulators of stem cell fate
DC Field | Value | Language |
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dc.contributor.author | 최은미 | - |
dc.contributor.author | 최은현 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2014-12-18T09:50:55Z | - |
dc.date.available | 2014-12-18T09:50:55Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88943 | - |
dc.description.abstract | Mounting evidence in stem cell biology has shown that microRNAs (miRNAs) play a crucial role in cell fate specification, including stem cell self-renewal, lineage-specific differentiation, and somatic cell reprogramming. These functions are tightly regulated by specific gene expression patterns that involve miRNAs and transcription factors. To maintain stem cell pluripotency, specific miRNAs suppress transcription factors that promote differentiation, whereas to initiate differentiation, lineage-specific miRNAs are upregulated via the inhibition of transcription factors that promote self-renewal. Small molecules can be used in a similar manner as natural miRNAs, and a number of natural and synthetic small molecules have been isolated and developed to regulate stem cell fate. Using miRNAs as novel regulators of stem cell fate will provide insight into stem cell biology and aid in understanding the molecular mechanisms and crosstalk between miRNAs and stem cells. Ultimately, advances in the regulation of stem cell fate will contribute to the development of effective medical therapies for tissue repair and regeneration. This review summarizes the current insights into stem cell fate determination by miRNAs with a focus on stem cell self-renewal, differentiation, and reprogramming. Small molecules that control stem cell fate are also highlighted. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | WORLD JOURNAL OF STEM CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | MicroRNAs as novel regulators of stem cell fate | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Eunhyun Choi | - |
dc.contributor.googleauthor | Eunmi Choi | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.4252/wjsc.v5.i4.172 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04162 | - |
dc.contributor.localId | A04456 | - |
dc.contributor.localId | A04151 | - |
dc.relation.journalcode | J02801 | - |
dc.identifier.eissn | 1948-0210 | - |
dc.identifier.pmid | 24179605 | - |
dc.subject.keyword | Differentiation | - |
dc.subject.keyword | MicroRNA | - |
dc.subject.keyword | Reprogramming | - |
dc.subject.keyword | Self-renewal | - |
dc.subject.keyword | Small molecule | - |
dc.subject.keyword | Stem cell fate | - |
dc.contributor.alternativeName | Choi, Eun Mi | - |
dc.contributor.alternativeName | Choi, Eun Hyun | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Choi, Eun Hyun | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Choi, Eun Mi | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 187 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF STEM CELLS, Vol.5(4) : 172-187, 2013 | - |
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