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Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty

Authors
 Hyun-Wook Chae  ;  Ah-Reum Kwon  ;  Duk-Hee Kim  ;  Ho-Seong Kim 
Citation
 ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, Vol.18(2) : 81-84, 2013 
Journal Title
 ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 
ISSN
 2287-1012 
Issue Date
2013
Keywords
Estradiol ; Lipid ; Precocious puberty ; Sex hormone-binding globulin
Abstract
Purpose: Sex hormone-binding globulin (SHBG) modulates the availability of biologically active free sex hormones. The regulatory role of SHBG might be important in the relationship between hormone levels and the modification of lipid profiles in girls with precocious puberty. However, few studies have evaluated the relationship of SHBG, free estradiol index (FEI), and lipid levels in these girls. Methods: One hundred and nine girls less than 8 years of age with pubertal development were enrolled. FEI was calculated with SHBG and estradiol (E2). We analyzed SHBG between peak luteinizing hormone (LH)≥5 (IU/L) (group 1) and LH<5 (IU/L) (group 2) through a gonadotropin releasing hormone stimulation test. Results: Body mass index (BMI) standard deviation score (SDS) was higher in group 2 than in group 1 (P =0.004). Serum SHBG levels did not differ and FEI was not higher in group 1 (P =0.122). Serum cholesterol, HDL, and LDL did not differ; however, triglyceride levels were higher in group 2 (P =0.023). SHBG was negatively correlated with bone age advancement, BMI, BMI SDS, and FEI, and was positively correlated with HDL. However, SHBG was not correlated with E2 or peak LH. Conclusion: Serum SHBG itself might not be associated with precocious puberty in girls, but it might be related to BMI and lipid profiles. Further studies are needed to reveal the relationship between sex hormone and obesity in girls with precocious puberty.
Files in This Item:
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DOI
10.6065/apem.2013.18.2.81
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ah Reum(권아름) ORCID logo https://orcid.org/0000-0002-9692-2135
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88879
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