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The prevalence and risk factors of vertebral fractures in Korean patients with type 2 diabetes

Authors
 Dong Jin Chung  ;  Hyung Jin Choi  ;  Yoon-Sok Chung  ;  Sung Kil Lim  ;  Seoung-Oh Yang  ;  Chan Soo Shin 
Citation
 JOURNAL OF BONE AND MINERAL METABOLISM, Vol.31(2) : 161-168, 2013 
Journal Title
 JOURNAL OF BONE AND MINERAL METABOLISM 
ISSN
 0914-8779 
Issue Date
2013
MeSH
Aged ; Aged, 80 and over ; Bone Density ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Humans ; Middle Aged ; Multivariate Analysis ; Postmenopause ; Prevalence ; Republic of Korea/epidemiology ; Risk Factors ; Spinal Fractures/epidemiology* ; Spinal Fractures/etiology* ; Spinal Fractures/physiopathology
Keywords
Vertebral fractures ; Type 2 diabetes ; Prevalence ; Risk factor
Abstract
Although type 2 diabetes mellitus (T2DM) has been associated with an increase in fracture risk, there is no data regarding the prevalence of vertebral fractures or its risk factors for patients with T2DM in Korea. In this cross-sectional study, we recruited postmenopausal women with T2DM from 24 tertiary hospital diabetes clinics in Korea. Prevalent vertebral fractures were identified on lateral spinal radiographs of thoracolumbar vertebrae by vertebral morphometry. Demographic and biochemical characteristics related to diabetes were obtained, and bone mineral density of the lumbar spine and femoral neck, which was available in 752 (33.6 %) and 675 (30.1 %) patients, respectively, was also analyzed. Of the 2239 subjects recruited (mean age 63.9 years), a total of 970 (43.3 %) subjects had vertebral fractures. In the bivariate analysis, history of fragility fractures after 50 years of age, microalbuminuria, presence of cardiovascular disease (myocardial infarction, angina, cerebrovascular complications of cardiovascular disease), and presence of osteoporosis at the total hip were significantly associated with the presence of vertebral fractures, after adjusting for age. In the multivariate analysis, the presence of cardiovascular diseases in addition to advancing age and history of fragility fractures was significantly associated with increased odds of vertebral fractures. Vertebral fractures were highly prevalent in postmenopausal women with T2DM in this study conducted in Korea, and the presence of cardiovascular disease, in addition to older age and history of fragility fractures, was significantly associated with the presence of vertebral fractures.
Full Text
http://link.springer.com/article/10.1007%2Fs00774-012-0398-5
DOI
10.1007/s00774-012-0398-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88819
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