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Two Cases of Humoral Hypercalcemia of Malignancy in Metastatic Cholangiocarcinoma

Authors
 Seungtaek Lim  ;  Jungwoo Han  ;  Kyeong Hye Park  ;  Won Jai Jung  ;  Yong Kang Lee  ;  Ara Choi  ;  Young Jae Kim  ;  Jong-Chan Lee  ;  Hye Jin Choi 
Citation
 Cancer Research and Treatment, Vol.45(2) : 145-149, 2013 
Journal Title
 Cancer Research and Treatment 
ISSN
 1598-2998 
Issue Date
2013
Abstract
Humoral hypercalcemia of malignancy (HHM) is rarely associated with cholangiocarcinoma (CC), and represents dismal prognosis. A 63-year-old male was admitted for evaluation of an intrahepatic mass. He was diagnosed with HHM associated with locally advanced CC. As the tumor responded to the concurrent chemoradiotherapy with capecitabine and cisplatin, serum calcium level was normalized. However, according to the disease progression, he suffered recurrence of HHM and he expired approximately one year after initial diagnosis. A 68-year-old male who presented with abdominal pain was diagnosed with metastatic CC. After the eighth cycle of gemcitabine and cisplatin, progression of the disease was found with HHM. He was treated with the best supportive care, until his demise approximately one month after the diagnosis of HHM. We report on two cases of HHM associated with CC that demonstrate strong correlation between hypercalcemia and disease burden.
Files in This Item:
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DOI
10.4143/crt.2013.45.2.145
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김영재(Kim, Young Jae)
이용강(Lee, Yong Kang)
임승택(Lim, Seung Taek)
정원재(Jung, Won Jai)
최아라(Choi, A Ra)
최혜진(Choi, Hye Jin)
한정우(Han, Jung Woo) ORCID logo https://orcid.org/0000-0001-8936-1205
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88722
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