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Two Cases of Humoral Hypercalcemia of Malignancy in Metastatic Cholangiocarcinoma

Authors
 Seungtaek Lim  ;  Jungwoo Han  ;  Kyeong Hye Park  ;  Won Jai Jung  ;  Yong Kang Lee  ;  Ara Choi  ;  Young Jae Kim  ;  Jong-Chan Lee  ;  Hye Jin Choi 
Citation
 Cancer Research and Treatment, Vol.45(2) : 145-149, 2013 
Journal Title
 Cancer Research and Treatment 
ISSN
 1598-2998 
Issue Date
2013
Keywords
Cholangiocarcinoma ; Hypercalcemia ; Parathyroid hormone-related protein
Abstract
Humoral hypercalcemia of malignancy (HHM) is rarely associated with cholangiocarcinoma (CC), and represents dismal prognosis. A 63-year-old male was admitted for evaluation of an intrahepatic mass. He was diagnosed with HHM associated with locally advanced CC. As the tumor responded to the concurrent chemoradiotherapy with capecitabine and cisplatin, serum calcium level was normalized. However, according to the disease progression, he suffered recurrence of HHM and he expired approximately one year after initial diagnosis. A 68-year-old male who presented with abdominal pain was diagnosed with metastatic CC. After the eighth cycle of gemcitabine and cisplatin, progression of the disease was found with HHM. He was treated with the best supportive care, until his demise approximately one month after the diagnosis of HHM. We report on two cases of HHM associated with CC that demonstrate strong correlation between hypercalcemia and disease burden.
Files in This Item:
T201304526.pdf Download
DOI
10.4143/crt.2013.45.2.145
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jae(김영재)
Lee, Yong Kang(이용강)
Lim, Seung Taek(임승택)
Jung, Won Jai(정원재)
Choi, A Ra(최아라)
Choi, Hye Jin(최혜진) ORCID logo https://orcid.org/0000-0001-5917-1400
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88722
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