Cited 21 times in
A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.contributor.author | 손정호 | - |
dc.contributor.author | 이재현 | - |
dc.date.accessioned | 2014-12-18T09:41:51Z | - |
dc.date.available | 2014-12-18T09:41:51Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88656 | - |
dc.description.abstract | Asthma is a chronic inflammatory disease induced by Type 2 helper T cells and eosinophils. Vascular cell adhesion molecule-1 (VCAM-1) has been implicated in recruiting eosinophils and lymphocytes to pathological sites in asthma as a regulatory receptor. Accordingly, monoclonal antibody (mAb) against VCAM-1 may attenuate allergic inflammation and pathophysiological features of asthma. We attempted to evaluate whether a recently developed human anti-VCAM-1 mAb can inhibit the pathophysiological features of asthma in a murine asthma model induced by ovalbumin (OVA). Leucocyte adhesion inhibition assay was performed to evaluate the in vitro blocking activity of human anti-VCAM-1 mAb. OVA-sensitized BALB/c mice were treated with human anti-VCAM-1 mAb or isotype control Ab before intranasal OVA challenge. We evaluated airway hyperresponsiveness (AHR) and bronchoalveolar lavage fluid analysis, measured inflammatory cytokines and examined histopathological features. The human anti-VCAM-1 mAb bound to human and mouse VCAM-1 molecules and inhibited adhesion of human leucocytes in vitro. AHR and inflammatory cell counts in bronchoalveolar lavage fluid were reduced in mice treated with human anti-VCAM-1 mAb as compared with a control Ab. The levels of interleukin (IL)-5 and IL-13, as well as transforming growth factor-β, in lung tissue were decreased in treated mice. Human anti-VCAM-1 mAb reduced goblet cell hyperplasia and peribronchial fibrosis. In vivo VCAM-1 expression decreased in the treated group. In conclusion, human anti-VCAM-1 mAb attenuated allergic inflammation and the pathophysiological features of asthma in OVA-induced murine asthma model. The results suggested that human anti-VCAM-1 mAb could potentially be used as an additional anti-asthma therapeutic medicine. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/immunology* | - |
dc.subject.MESH | Asthma/immunology* | - |
dc.subject.MESH | Asthma/therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Vascular Cell Adhesion Molecule-1/immunology* | - |
dc.title | A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Jung-Ho Sohn | - |
dc.contributor.googleauthor | Su Yeon Ryu | - |
dc.contributor.googleauthor | Chein-Soo Hong | - |
dc.contributor.googleauthor | Kyung D. Moon | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.identifier.doi | 10.1111/jcmm.12102 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A01993 | - |
dc.contributor.localId | A03086 | - |
dc.relation.journalcode | J01302 | - |
dc.identifier.eissn | 1582-4934 | - |
dc.identifier.pmid | 23855490 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12102/abstract | - |
dc.subject.keyword | VCAM-1 | - |
dc.subject.keyword | allergic inflammation | - |
dc.subject.keyword | anti-inflammatory effect | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | cell adhesion molecule | - |
dc.subject.keyword | monoclonal antibody | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Sohn, Jung Ho | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Sohn, Jung Ho | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1271 | - |
dc.citation.endPage | 1281 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Vol.17(10) : 1271-1281, 2013 | - |
dc.identifier.rimsid | 33387 | - |
dc.type.rims | ART | - |
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