Angiogenesis Inhibitors/adverse effects* ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Diphosphonates/therapeutic use ; Everolimus ; Follow-Up Studies ; Humans ; Imidazoles/therapeutic use ; Male ; Mandibular Diseases/chemically induced* ; Middle Aged ; Osteonecrosis/chemically induced* ; Sirolimus/adverse effects ; Sirolimus/analogs & derivatives* ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods
Keywords
ARONJ ; Anti-angiogenic agent ; Anti-resorptive agent related osteonecrosis of the jaw ; Everolimus
Abstract
Antiresorptive agent-related osteonecrosis of the jaw results in appreciable morbidity in affected patients. Nowadays many physicians prescribe an antiangiogenic agent for the management of malignant metastases. Everolimus is a serine-threonine kinase that acts as an inhibitor of mammalian target of rapamycin, which results in reduced growth of cells, angiogenesis, and survival of cells. We report the first case to our knowledge of osteonecrosis of the jaw that seemed to result from the additive effect of everolimus.