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Osteonecrosis of the jaw related to everolimus: a case report

Authors
 Dong Wook Kim  ;  Young-Soo Jung  ;  Hyung-Sik Park  ;  Hwi-Dong Jung 
Citation
 BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, Vol.51(8) : 302-304, 2013 
Journal Title
 BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 
ISSN
 0266-4356 
Issue Date
2013
MeSH
Angiogenesis Inhibitors/adverse effects* ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Diphosphonates/therapeutic use ; Everolimus ; Follow-Up Studies ; Humans ; Imidazoles/therapeutic use ; Male ; Mandibular Diseases/chemically induced* ; Middle Aged ; Osteonecrosis/chemically induced* ; Sirolimus/adverse effects ; Sirolimus/analogs & derivatives* ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods
Keywords
ARONJ ; Anti-angiogenic agent ; Anti-resorptive agent related osteonecrosis of the jaw ; Everolimus
Abstract
Antiresorptive agent-related osteonecrosis of the jaw results in appreciable morbidity in affected patients. Nowadays many physicians prescribe an antiangiogenic agent for the management of malignant metastases. Everolimus is a serine-threonine kinase that acts as an inhibitor of mammalian target of rapamycin, which results in reduced growth of cells, angiogenesis, and survival of cells. We report the first case to our knowledge of osteonecrosis of the jaw that seemed to result from the additive effect of everolimus.
Full Text
http://www.sciencedirect.com/science/article/pii/S0266435613004269
DOI
10.1016/j.bjoms.2013.09.008
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0001-6167-6475
Park, Hyung Sik(박형식)
Jung, Young Soo(정영수) ORCID logo https://orcid.org/0000-0001-5831-6508
Jung, Hwi Dong(정휘동) ORCID logo https://orcid.org/0000-0003-1025-8323
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88625
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