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Prognostic value of 18F-fluorodeoxyglucose positron emission tomography in patients with resectable pancreatic cancer

Authors
 Hye Jin Choi  ;  Chang Moo Kang  ;  Woo Jung Lee  ;  Si Young Song  ;  Arthur Cho  ;  Mijin Yun  ;  Jong Doo Lee  ;  Joo Hang Kim  ;  Jae-Hoon Lee 
Citation
 Yonsei Medical Journal, Vol.54(6) : 1377-1383, 2013 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2013
Abstract
PURPOSE: We evaluated the prognostic value of (18)F-2-fluoro-2-deoxyglucose positron emission tomography (FDG PET) in patients with resectable pancreatic cancer. MATERIALS AND METHODS: We retrospectively reviewed the medical records of pancreatic cancer patients who underwent curative resection, which included 64 consecutive patients who had preoperative FDG PET scans. For statistical analysis, the maximal standardized uptake value (SUVmax) of primary pancreatic cancer was measured. Survival time was estimated by the Kaplan-Meier method, and Cox's proportional hazard model was used to determine whether SUVmax added new predictive information concerning survival together with known prognostic factors. p<0.05 indicated statistical significance. RESULTS: Overall survival (OS) and disease- free survival (DFS) were respectively 42.9 months (27.6-58.2; 95% CI) and 14.9 months (10.1-19.7; 95% CI). When subjects were divided into two groups according to SUVmax with a cutoff value of 3.5, the high SUVmax group (n=32; SUVmax >3.5) showed significantly shorter OS and DFS than the low SUVmax group. Multivariate analysis of OS and DFS showed that both high SUVmax and poor tumor differentiation were independent poor prognostic factors. CONCLUSION: Our study showed that degree of FDG uptake was an independent prognostic factor in pancreatic cancer patients who underwent curative resection.
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DOI
10.3349/ymj.2013.54.6.1377
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
강창무(Kang, Chang Moo) ORCID logo https://orcid.org/0000-0002-5382-4658
김주항(Kim, Joo Hang)
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이우정(Lee, Woo Jung) ORCID logo https://orcid.org/0000-0001-9273-261X
이재훈(Lee, Jae Hoon)
이종두(Lee, Jong Doo)
조응혁(Cho, Arthur Eung Hyuck) ORCID logo https://orcid.org/0000-0001-8670-2473
최혜진(Choi, Hye Jin)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88615
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