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Prognostic value of 18F-fluorodeoxyglucose positron emission tomography in patients with resectable pancreatic cancer

Authors
 Hye Jin Choi  ;  Chang Moo Kang  ;  Woo Jung Lee  ;  Si Young Song  ;  Arthur Cho  ;  Mijin Yun  ;  Jong Doo Lee  ;  Joo Hang Kim  ;  Jae-Hoon Lee 
Citation
 Yonsei Medical Journal, Vol.54(6) : 1377-1383, 2013 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18* ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Pancreatic Neoplasms/diagnostic imaging* ; Pancreatic Neoplasms/pathology* ; Pancreatic Neoplasms/surgery ; Positron Emission Tomography Computed Tomography*
Keywords
disease-free survival ; fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ; lymph node metastasis ; lymph node to tumor standardized uptake value ratio ; overall survival ; pancreatic cancer
Abstract
PURPOSE: We evaluated the prognostic value of (18)F-2-fluoro-2-deoxyglucose positron emission tomography (FDG PET) in patients with resectable pancreatic cancer. MATERIALS AND METHODS: We retrospectively reviewed the medical records of pancreatic cancer patients who underwent curative resection, which included 64 consecutive patients who had preoperative FDG PET scans. For statistical analysis, the maximal standardized uptake value (SUVmax) of primary pancreatic cancer was measured. Survival time was estimated by the Kaplan-Meier method, and Cox's proportional hazard model was used to determine whether SUVmax added new predictive information concerning survival together with known prognostic factors. p<0.05 indicated statistical significance. RESULTS: Overall survival (OS) and disease- free survival (DFS) were respectively 42.9 months (27.6-58.2; 95% CI) and 14.9 months (10.1-19.7; 95% CI). When subjects were divided into two groups according to SUVmax with a cutoff value of 3.5, the high SUVmax group (n=32; SUVmax >3.5) showed significantly shorter OS and DFS than the low SUVmax group. Multivariate analysis of OS and DFS showed that both high SUVmax and poor tumor differentiation were independent poor prognostic factors. CONCLUSION: Our study showed that degree of FDG uptake was an independent prognostic factor in pancreatic cancer patients who underwent curative resection.
Files in This Item:
T201304311.pdf Download
DOI
10.3349/ymj.2013.54.6.1377
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Joo Hang(김주항)
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Jong Doo(이종두)
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
Choi, Hye Jin(최혜진) ORCID logo https://orcid.org/0000-0001-5917-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88615
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