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Heparin-induced Thrombocytopenia Type II after Free Flap Operation

Authors
 Jiwoong Baek  ;  Jung Hyun Park  ;  In-Ho Cha  ;  Hyung Jun Kim 
Citation
 Journal of Korean Association Maxillofacial Plastic Reconstructive Surgery (대한악안면성형재건외과학회지), Vol.35(6) : 408-411, 2013 
Journal Title
 Journal of Korean Association Maxillofacial Plastic Reconstructive Surgery (대한악안면성형재건외과학회지) 
ISSN
 1225-4207 
Issue Date
2013
Keywords
HIT type II ; Heparin-induced thrombocytopenia ; Free tissue flaps ; Heparin
Abstract
After radical excision of a tumor in the maxillofacial area, functional and esthetic reconstruction is needed, including flap surgery. Among the many etiologies of flap failure, venous thrombosis is one of the most frequent. Heparin is used routinely in the effort to avoid development of venous thrombosis. In rare cases, heparin-induced thrombocytopenia (HIT) type II occurs due to exposure to heparin. Heparin attached to platelet factor 4 forms a PF4/heparin-immunoglobulin G immune complex on platelet surfaces. This complex activates platelets, which leads to multiple coagulation in venous and arterial blood. We report here on a rare occurrence of HIT type II following fibula free flap surgery.
Files in This Item:
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DOI
10.14402/jkamprs.2013.35.6.408
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88591
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