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Neuroanatomical Heterogeneity of Essential Tremor According to Propranolol Response

Authors
 Seok Jong Chung  ;  Hunki Kwon  ;  Dong-Kyun Lee  ;  Jin Yong Hong  ;  Mun-Kyung Sunwoo  ;  Young H. Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
Citation
 PLoS One, Vol.8(12) : e84054, 2013 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2013
Abstract
BACKGROUND: Recent studies have suggested that essential tremor (ET) is a more complex and heterogeneous clinical entity than initially thought. In the present study, we assessed the pattern of cortical thickness and diffusion tensor white matter (WM) changes in patients with ET according to the response to propranolol to explore the pathogenesis underlying the clinical heterogeneity of ET. METHODS: A total of 32 patients with drug naive ET were recruited prospectively from the Movement Disorders outpatient clinic. The patients were divided into a propranolol-responder group (n = 18) and a non-responder group (n = 14). We analyzed the pattern of cortical thickness and diffusion tensor WM changes between these two groups and performed correlation analysis between imaging and clinical parameters. RESULTS: There were no significant differences in demographic characteristics, general cognition, or results of detailed neuropsychological tests between the groups. The non-responder group showed more severe cortical atrophy in the left orbitofrontal cortex and right temporal cortex relative to responders. However, the responders exhibited significantly lower fractional anisotropy values in the bilateral frontal, corpus callosal, and right parietotemporal WM compared with the non-responder group. There were no significant clusters where the cortical thickness or WM alterations were significantly correlated with initial tremor severity or disease duration. CONCLUSIONS: The present data suggest that patients with ET have heterogeneous cortical thinning and WM alteration with respect to responsiveness to propranolol, suggesting that propranolol responsiveness may be a predictive factor to determine ET subtypes in terms of neuroanatomical heterogeneity.
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DOI
10.1371/journal.pone.0084054
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
선우문경(Sunwoo, Mun Kyung)
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
이필휴(Lee, Phil Hyu)
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
홍진용(Hong, Jin Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88589
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