159 204

Cited 7 times in

Neuroanatomical Heterogeneity of Essential Tremor According to Propranolol Response

Authors
 Seok Jong Chung  ;  Hunki Kwon  ;  Dong-Kyun Lee  ;  Jin Yong Hong  ;  Mun-Kyung Sunwoo  ;  Young H. Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
Citation
 PLOS ONE, Vol.8(12) : e84054, 2013 
Journal Title
 PLOS ONE 
Issue Date
2013
MeSH
Adrenergic beta-Antagonists/therapeutic use ; Aged ; Anisotropy ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology* ; Diffusion Tensor Imaging* ; Essential Tremor/diagnosis ; Essential Tremor/drug therapy ; Essential Tremor/pathology* ; Essential Tremor/physiopathology* ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Prognosis ; Propranolol/therapeutic use ; Treatment Outcome
Keywords
Adrenergic beta-Antagonists/therapeutic use ; Aged ; Anisotropy ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology* ; Diffusion Tensor Imaging* ; Essential Tremor/diagnosis ; Essential Tremor/drug therapy ; Essential Tremor/pathology* ; Essential Tremor/physiopathology* ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Prognosis ; Propranolol/therapeutic use ; Treatment Outcome
Abstract
BACKGROUND: Recent studies have suggested that essential tremor (ET) is a more complex and heterogeneous clinical entity than initially thought. In the present study, we assessed the pattern of cortical thickness and diffusion tensor white matter (WM) changes in patients with ET according to the response to propranolol to explore the pathogenesis underlying the clinical heterogeneity of ET. METHODS: A total of 32 patients with drug naive ET were recruited prospectively from the Movement Disorders outpatient clinic. The patients were divided into a propranolol-responder group (n = 18) and a non-responder group (n = 14). We analyzed the pattern of cortical thickness and diffusion tensor WM changes between these two groups and performed correlation analysis between imaging and clinical parameters. RESULTS: There were no significant differences in demographic characteristics, general cognition, or results of detailed neuropsychological tests between the groups. The non-responder group showed more severe cortical atrophy in the left orbitofrontal cortex and right temporal cortex relative to responders. However, the responders exhibited significantly lower fractional anisotropy values in the bilateral frontal, corpus callosal, and right parietotemporal WM compared with the non-responder group. There were no significant clusters where the cortical thickness or WM alterations were significantly correlated with initial tremor severity or disease duration. CONCLUSIONS: The present data suggest that patients with ET have heterogeneous cortical thinning and WM alteration with respect to responsiveness to propranolol, suggesting that propranolol responsiveness may be a predictive factor to determine ET subtypes in terms of neuroanatomical heterogeneity.
Files in This Item:
T201304226.pdf Download
DOI
10.1371/journal.pone.0084054
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
Hong, Jin Yong(홍진용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88589
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse