200 309

Cited 10 times in

Prognostic Discrimination Using a 70-Gene Signature among Patients with Estrogen Receptor-Positive Breast Cancer and an Intermediate 21-Gene Recurrence Score

Authors
 Sung Gwe Ahn  ;  Hak Min Lee  ;  Hak Woo Lee  ;  Seung Ah Lee  ;  Se-Ra Lee  ;  Sun-Hee Leem  ;  Joon Jeong  ;  In-Sun Chu 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.14(12) : 23685-23699, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2013
MeSH
Adult ; Aged ; Aurora Kinases/genetics ; Aurora Kinases/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis* ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Chemotherapy, Adjuvant ; Cluster Analysis ; Female ; Forkhead Box Protein M1 ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Profiling* ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Kaplan-Meier Estimate ; Middle Aged ; Neoplasm Recurrence, Local* ; Predictive Value of Tests ; Prognosis ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism* ; Young Adult
Keywords
breast cancer ; estrogen receptor ; recurrence score ; 70-gene signature ; FOXM1 ; AURKA ; AURKB ; BIRC5
Abstract
The Oncotype DX® recurrence score (RS) predictor has been clinically utilized to appropriately select adjuvant chemotherapy for patients with estrogen receptor (ER)-positive early breast cancer. However, the selection of chemotherapy for patients with intermediate RSs remains controversial. We assessed the prognostic value of a 70-gene signature (70GS) among patients with ER-positive breast cancer and intermediate RSs. In addition, we sought to identify genes associated with poor 70GS scores based on gene expression profiling (GEP). GEP was performed using gene expression data from 186 patients with ER-positive breast cancer. The RS and 70GS score were calculated on the basis of GEP. Among 186 patients, 82 ER-positive patients with intermediate RSs were identified. These patients were stratified by 70GS, overall survival (OS) significantly differed according to 70GS (p = 0.013). In a supervised hierarchical analysis according to 70GS, the expression of several representative genes for cell proliferation was significantly higher in the poor 70GS cluster than in the good 70GS cluster. Furthermore, among these patients, FOXM1, AURKA, AURKB, and BIRC5 displayed prognostic significance for OS. In conclusion, 70GS can help to discriminate survival differences among ER-positive patients with intermediate RSs. FOXM1, AURKA, AURKB, and BIRC5, are associated with poor 70GS scores.
Files in This Item:
T201304219.pdf Download
DOI
10.3390/ijms141223685
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Lee, Hak Min(이학민)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88584
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links