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Cited 33 times in

Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype

DC FieldValueLanguage
dc.contributor.author김종원-
dc.contributor.author설소영-
dc.contributor.author윤선옥-
dc.contributor.author임재윤-
dc.contributor.author조재용-
dc.contributor.author최승호-
dc.contributor.author홍순원-
dc.date.accessioned2014-12-18T09:34:01Z-
dc.date.available2014-12-18T09:34:01Z-
dc.date.issued2013-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88410-
dc.description.abstractAIM: To identify molecular biologic differences between two gastric adenocarcinoma subgroups presenting different prognoses through the analysis of microRNA and protein expression. METHODS: Array technologies were used to generate 1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric cancer. For the integrative analysis, we used established mRNA expression data published in our previous study. Whole mRNA expression levels were acquired from microarray data for 60 identical gastric cancer patients. Two gastric adenocarcinoma subgroups with distinct mRNA expression profiles presented distinctly different prognoses. MicroRNA and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two different prognostic groups. Aberrantly expressed microRNA, associated mRNA, and protein in patients with poor-prognosis gastric cancer were validated by quantitative reverse transcription polymerase chain reaction and immunochemistry in independent patients. RESULTS: We obtained the expression data of 1146 microRNAs and 124 cancer-related proteins. Four microRNAs were aberrantly expressed in the two prognostic groups and in cancer vs non-cancer tissues (P < 0.05). In the poor-prognosis group, miR-196b, miR-135b, and miR-93 were up-regulated and miR-29c* was down-regulated. miR-196b expression positively correlated with Homeobox A10 (HOXA10) expression (r = 0.726, P < 0.001), which was significantly increased in poor-prognosis patients (P < 0.001). Comparing gastric cancer with non-cancer tissues, 46/124 proteins showed differential expression (P < 0.05); COX2 (P < 0.001) and cyclin B1 (P = 0.017) were clearly over-expressed in the poor-prognosis group. CONCLUSION: Co-activation of miR-196b and HOXA10 characterized a poor-prognosis subgroup of patients with gastric cancer. Elucidation of the biologic function of miR-196b and HOXA10 is warranted.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfWorld Journal of Gastroenterology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOverexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorSo-Young Seol-
dc.contributor.googleauthorSoon Won Hong-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorJu-Seog Lee-
dc.contributor.googleauthorJae Yong Cho-
dc.identifier.doi10.3748/wjg.v19.i41.7078-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01939-
dc.contributor.localIdA02566-
dc.contributor.localIdA03398-
dc.contributor.localIdA03899-
dc.contributor.localIdA04411-
dc.contributor.localIdA04102-
dc.contributor.localIdA00925-
dc.relation.journalcodeJ02795-
dc.contributor.alternativeNameKim, Jong Won-
dc.contributor.alternativeNameSeol, So Young-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorSeol, So Young-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorLim, Jae Yun-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Jong Won-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number41-
dc.citation.startPage7078-
dc.citation.endPage7088-
dc.identifier.bibliographicCitationWorld Journal of Gastroenterology, Vol.19(41) : 7078-7088, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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