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Blood characteristics effect on pulse wave velocity

Authors
 Jong Youn Kim  ;  Jihyun Yoon  ;  Minhee Cho  ;  Byoung-Kwon Lee  ;  Ali Karimi  ;  Sehyun Shin 
Citation
 CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, Vol.55(1) : 193-203, 2013 
Journal Title
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
ISSN
 1386-0291 
Issue Date
2013
MeSH
Arteries/physiology ; Blood Flow Velocity ; Female ; Hemorheology ; Humans ; Male ; Middle Aged ; Pulsatile Flow/physiology* ; Pulse Wave Analysis/methods* ; Vascular Resistance/physiology*
Keywords
Vascular stiffness ; blood density ; pulse wave velocity
Abstract
PWV, a surrogate marker for vascular stiffness, can be also expressed by the Bramwell-Hill equation. The effect of blood density to PWV has been ignored, because variation of blood density is assumed to be negligible. In some clinical situation, blood density could be changed, and blood density as a mechanical property of blood flow might affect to PWV. While the elastic property plays an important role in determining the wave propagation in an elastic tube, our assumption is that there might be some relation between blood flow and vascular wall, and that the characteristics of blood flow might influence PWV. This study was objected to investigate the role of mechanical and hemorheologic parameters on PWV in subjects with cardiovascular disease. We have measured and analyzed the PWV, hemorheologic parameters, and other clinical parameters in 814 patients with coronary arterial disease scheduled for coronary angiography. There is no commercial method for measuring whole blood density. So, we defined the density score, which is sum of hemoglobin and total protein. And the hemorheologic parameters were measured within 4 hours after sampling by automated microfluidic hemorheometer. And the effect of all the clinical and hemorheologic parameter on PWV was analyzed by multiple linear regression analysis. Many clinical parameters including age and blood pressure, high shear WBV and ESR as hemorheologic parameters, and density score were correlated well with ba-PWV. However, many clinical variables, high shear WBV and ESR lost the independent significance on multivariable regression analysis. Only age, SBP, and density score were independent variables (p < 0.001). In conclusion, density score as a mechanical property of blood might be suggested as an independent variable influencing PWV in addition to age and blood pressure, but hemorheologic parameters, such as RBC deformability, aggregation, and whole blood viscosity do not affect PWV independently.
Full Text
http://iospress.metapress.com/content/hg11lm15157n6017/?genre=article&issn=1386-0291&volume=55&issue=1&spage=193
DOI
10.3233/CH-131702
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Yoon, Ji Hyun(윤지현)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88407
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