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Optical coherence tomography analysis of strut coverage in biolimus- and sirolimus-eluting stents: 3-Month and 12-month serial follow-up

 Byeong-Keuk Kim  ;  Myeong-Ki Hong  ;  Dong-Ho Shin  ;  Jung-Sun Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang 
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.168(5) : 4617-4623, 2013 
Journal Title
Issue Date
Antineoplastic Agents, Phytogenic/pharmacology ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery* ; Coronary Vessels/pathology* ; Coronary Vessels/surgery ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Paclitaxel/pharmacology* ; Prospective Studies ; Prosthesis Design ; Reproducibility of Results ; Sirolimus/analogs & derivatives* ; Sirolimus/pharmacology ; Time Factors ; Tomography, Optical Coherence/methods* ; Treatment Outcome ; Tunica Intima/pathology
Coronary artery disease ; Drug-eluting stent ; Optical coherence tomography
BACKGROUND: No randomized studies have been conducted to investigate serial changes in optical coherence tomography (OCT) analyses following implantation of biolimus-A9-eluting stents (BES) and sirolimus-eluting stents (SES). METHODS: A total of 60 patients fulfilling the study criteria were randomly assigned into BES (n=30) and SES (n=30) implantation groups. Serial OCT evaluation at post-procedure, 3- and 12-month follow-up was performed in 46 patients [BES (n=22) and SES (n=24)]. OCT analyses were compared according to the type of stents and the follow-up time intervals. The percentage of uncovered struts was defined as the ratio of uncovered struts to total struts in all cross-sections. The primary endpoint was the percentage change (Δ) of uncovered struts in the 3- and 12-month follow-up samples. RESULTS: The percentage of uncovered struts at the 3-month time period was not significantly different in the BES and SES groups; the median value (interquartile range) was 14.7% (0.0-23.4) versus 8.6% (0.7-21.5) (p=0.98), respectively. However, OCT at the 12-month follow-up showed a significantly lower percentage of uncovered struts [2.6% (0.8-5.6) versus 6.2% (1.7-14.7), (p=0.028), respectively] without significant difference of neointimal thickness. BES showed a greater reduction of percentage Δ of uncovered struts from 3-12 months than that of SES [-17.2±14.5% versus -7.7±16.3%, respectively (p=0.043)]. CONCLUSIONS: Both drug-eluting stents showed a high percentage of incomplete strut coverage at 3 months. However, BES showed a significantly lower percentage of uncovered struts at 12 months compared to that of SES. This was achieved by superior strut coverage from 3 to 12 months.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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