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알렌드로네이트의 투여기간이 발치와의 치유에 미치는 영향: 예비실험

Other Titles
 The effect of alendronates administration duration on the healing of extraction socket in rats: pilot study 
 김지환  ;  홍종환  ;  최현민  ;  박영범  ;  문홍석 
 Journal of Korean Academy of Prosthodontics (대한치과보철학회지), Vol.51(3) : 175-182, 2013 
Journal Title
 Journal of Korean Academy of Prosthodontics (대한치과보철학회지) 
Issue Date
Alendronate ; Bisphosphonate ; Extraction socket ; bisphosphonate related osteonecrosis of jaw ; Wound healing
PURPOSE. The purpose of this study was to investigate the effect of different administration duration of alendronate on initial wound healing and new bone formation of extraction socket in rats. MATERIALS AND METHODS. Fifteen male Sprague-Dawley rats (body weight 130-140 g, 4 weeks old, male) were divided into control group (no alendronate administration) and experimental group (alendronate administration). Experimental group was subdivided into 1 week administrated group, 2 week administrated group, 4 week administrated group and 6 week administrated group according to duration of administration. For the experimental groups, during the designated time period (at the time of extraction, 1 week before extraction, 3 week before extraction and 5 week before extraction) till 1 week after extraction, rats were subcutaneously injected with Alendronate at the dose of 1.0 mg/Kg three times a week. Each specimen from 6 week experimental group and control group were used for microarray analysis, and other specimens were used for histological analysis. The rate of new bone formation within the extraction site and bone loss activity was analyzed using TRAP staining. Statistical analysis was performed using Kruskal Wallis test. (α=.05) RESULTS. After one week from the time of extraction, the rate of new bone formation within extraction site for the control group (16.77% ± 1.36%) compared to the 4 week experimental group (14.99% ± 6.26%) was lower. However, no statistically significant difference was found. Increase in the number of inactive lacuna (empty lacuna) and decrease in the number of TRAP positive cell were identified with increased duration of administration. There was no significant difference. CONCLUSION. The results of this study showed as the duration of Alendronate administration increased the rate of new bone formation decreased with loss of bone activity and reduced number of osteoclast.
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Appears in Collections:
5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hwan(김지환) ORCID logo https://orcid.org/0000-0002-0872-4906
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Park, Young Bum(박영범)
Choi, Hyun Min(최현민)
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