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Comparison of matrix-assisted laser desorption ionization–time-of-flight mass spectrometry assay with conventional methods for detection of IMP-6, VIM-2, NDM-1, SIM-1, KPC-1, OXA-23, and OXA-51 carbapenemase-producing Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae

Authors
 Wonmok Lee  ;  Hae-Sun Chung  ;  Yangsoon Lee  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Kyungwon Lee  ;  Yunsop Chong 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.77(3) : 227-230, 2013 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2013
MeSH
Acinetobacter/enzymology* ; Bacteriological Techniques/methods* ; Humans ; Klebsiella pneumoniae/enzymology* ; Pseudomonas aeruginosa/enzymology* ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods* ; Time Factors ; beta-Lactamases/analysis*
Keywords
Acinetobacter spp ; Carbapenemase ; MALDI-TOF MS ; OXA ; SIM-1
Abstract
Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry assay was able to detect carbapenemase producers, including SIM-1 or OXA-51, within 4 hours using 20 μL of 0.5 g/L ertapenem solution as a substrate. This assay is more rapid and accurate than the modified Hodge test and 3-dimensional extract bioassay. Hence, it can be used an alternative test to identify carbapenemase-mediated carbapenem resistance in Gram-negative bacteria.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889313003982
DOI
10.1016/j.diagmicrobio.2013.07.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yang Soon(이양순)
Lee, Won Mok(이원목)
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88292
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