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The expression of redox proteins in phyllodes tumor

Authors
 Sewha Kim  ;  Do Hee Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.141(3) : 365-374, 2013 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
2013
MeSH
Adult ; Breast Neoplasms/enzymology* ; Breast Neoplasms/pathology ; Carrier Proteins/metabolism ; Catalase/metabolism ; Epithelial Cells/enzymology ; Female ; Glutathione S-Transferase pi/metabolism ; Humans ; Middle Aged ; Neoplasm Grading ; Oxidation-Reduction ; Phyllodes Tumor/enzymology* ; Phyllodes Tumor/pathology ; Stromal Cells/enzymology ; Superoxide Dismutase/metabolism ; Thioredoxin Reductase 1/metabolism ; Tissue Array Analysis
Keywords
Breast ; Grade ; Phyllodes tumor ; Redox protein ; Metabolism
Abstract
This study aimed to investigate the associations between the expression of redox-related proteins which regulate reactive oxygen species (ROS) production and the histologic factors in phyllodes tumor (PT). We used tissue microarrays to analyze 193 PTs and performed immunohistochemical staining against five redox-related proteins including catalase, thioredoxin reductase (TxNR), glutathione S-transferase π (GST π), thioredoxin interacting protein (TxNIP), and manganese superoxide dismutase (MnSOD). We then compared the immunohistochemical results and histologic parameters. The 193 PTs were classified as benign (n = 145, 75.1 %), borderline (n = 33, 17.1 %), and malignant (n = 15, 7.8 %). With worsening histologic grade, the expression of catalase, TxNR, TxNIP, and MnSOD in the stromal component increased (P < 0.001), and GST π and MnSOD expression in the epithelial component increased (P = 0.014, and 0.038). Significant associations were found between the expression of catalse–TxNR, catalase–TxNIP, catalase–MnSOD, TxNR–TxNIP, TxNR–MnSOD, and TxNIP–MnSOD in both the epithelial and stromal components (P < 0.05). This study confirmed that the stromal expression of catalase, TxNR, TxNIP, and MnSOD increased with worsening histologic grade in PT, reflecting the change in ROS production during the malignant transformation of PT.
Full Text
http://link.springer.com/article/10.1007%2Fs10549-013-2701-0
DOI
10.1007/s10549-013-2701-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88280
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