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Expression of transient receptor potential channels in the ependymal cells of the developing rat brain
DC Field | Value | Language |
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dc.contributor.author | 이원택 | - |
dc.date.accessioned | 2014-12-18T09:27:53Z | - |
dc.date.available | 2014-12-18T09:27:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2093-3665 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88218 | - |
dc.description.abstract | Cerebrospinal fluid (CSF) plays an important role in providing brain tissue with a stable internal environment as well as in absorbing mechanical and thermal stresses. From its initial composition, derived from the amniotic fluid trapped by the closure of neuropores, CSF is modified by developing and differentiating ependymal cells lining the ventricular surface or forming the choroid plexus. Its osmolarity and ionic composition brings about a change through the action of many channels expressed on the ependymal cells. Some newly discovered transient receptor potential (TRP) channels are known to be expressed in the choroid plexus ependyma. To detect additional TRP channel expression, immunohistochemical screening was performed at the choroid plexus of 13-, 15-, 17-, and 19-day embryos, using antibodies against TRPV1, TRPV3, and TRPA1, and the expression was compared with those in the adult TRP channels. The level of TRP channel expression was higher in the choroid plexus which suggests more active functioning of TRP channels in the developing choroid plexus than the ventricular lining ependyma in the 15- and 17-day embryos. All the expression of TRP channels decreased at the 19th day of gestation. TRPA1 was expressed at a higher level than TRPV1 and TRPV3 in almost all stages in both the choroid plexus and ventricular lining epithelium. The highest level of TRPV1 and TRPV3 expression was observed in association with the glycogen deposits in the cytoplasm of the choroid plexus ependymal cells of the 15- and 17-day embryos. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Anatomy and Cell Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AdultMark | - |
dc.subject.MESH | Amniotic FluidMark | - |
dc.subject.MESH | AnimalsMark | - |
dc.subject.MESH | AntibodiesMark | - |
dc.subject.MESH | BrainMark | - |
dc.subject.MESH | Choroid PlexusMark | - |
dc.subject.MESH | CytoplasmMark | - |
dc.subject.MESH | Embryonic DevelopmentMark | - |
dc.subject.MESH | Embryonic StructuresMark | - |
dc.subject.MESH | EpendymaMark | - |
dc.subject.MESH | EpitheliumMark | - |
dc.subject.MESH | FemaleMark | - |
dc.subject.MESH | GlycogenMark | - |
dc.subject.MESH | HumansMark | - |
dc.subject.MESH | Mass ScreeningMark | - |
dc.subject.MESH | Osmolar ConcentrationMark | - |
dc.subject.MESH | PregnancyMark | - |
dc.subject.MESH | RatsMark | - |
dc.subject.MESH | Transient Receptor Potential Channels | - |
dc.title | Expression of transient receptor potential channels in the ependymal cells of the developing rat brain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Kwang Deog Jo | - |
dc.contributor.googleauthor | Kyu-Seok Lee | - |
dc.contributor.googleauthor | Won Taek Lee | - |
dc.contributor.googleauthor | Mi-Sun Hur | - |
dc.contributor.googleauthor | Ho-Jeong Kim | - |
dc.identifier.doi | 10.5115/acb.2013.46.1.68 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03007 | - |
dc.relation.journalcode | J00142 | - |
dc.identifier.pmid | 23560238 | - |
dc.subject.keyword | Choroid plexus | - |
dc.subject.keyword | Embryonic development | - |
dc.subject.keyword | Ependyma | - |
dc.subject.keyword | Transientreceptorpotentialchannels | - |
dc.contributor.alternativeName | Lee, Won Taek | - |
dc.contributor.affiliatedAuthor | Lee, Won Taek | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 78 | - |
dc.identifier.bibliographicCitation | Anatomy and Cell Biology, Vol.46(1) : 68-78, 2013 | - |
dc.identifier.rimsid | 33131 | - |
dc.type.rims | ART | - |
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