122 164

Cited 0 times in

Expression of autophagy-related proteins in phyllodes tumor.

Authors
 Sang Kyum Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
Citation
 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.6(10) : 2145-2156, 2013 
Journal Title
 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 
Issue Date
2013
MeSH
Adaptor Proteins, Signal Transducing/metabolism ; Adult ; Apoptosis Regulatory Proteins/metabolism ; Autophagy/physiology* ; Beclin-1 ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Disease-Free Survival ; Female ; Humans ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Phyllodes Tumor/metabolism* ; Phyllodes Tumor/pathology ; Prognosis ; Sequestosome-1 Protein ; Stromal Cells/metabolism* ; Stromal Cells/pathology
Keywords
Breast ; phyllodes tumor ; autophagy
Abstract
Phyllodes tumors (PTs) are classified as fibroepithelial tumors and their histologic grade is determined primarily by the features of the stromal component. In this study, we examined the expression profiles of autophagy-related proteins in the stromal component of PTs and analyzed their clinical implications. We selected 204 human PT samples which were excised and diagnosed at Severance Hospital from 2000 to 2008 and created tissue microarray (TMA) blocks. Immunohistochemical assays for autophagy-related proteins (beclin-1, LC3A, LC3B, and p62) were then performed on these samples. The surgical specimens from higher grade PTs less frequently displayed cytoplasmic expression of beclin-1, LC3A, LC3B, and p62 in the stromal component (p<0.001). In univariate analysis, the following profiles were associated with shorter disease-free survival and overall survival: nuclear beclin-1 positivity in the stromal component (p=0.013 and p=0.044, respectively), LC3A positivity in the stromal component (p<0.001 and p<0.001, respectively), and p62 positivity in the stromal component (p=0.012 and p=0.004, respectively). In conclusion, we determined that increased activity of autophagy-related proteins correlated with a higher histologic grade and poorer prognosis in PTs. These results lead us to conclude that the autophagy activity of the stromal cells plays a key role in the progression of PTs.
Files in This Item:
T201303619.pdf Download
DOI
24133593
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Sang Kyum(김상겸) ORCID logo https://orcid.org/0000-0003-0768-9923
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88217
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse