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A comparison of long term renal functional outcomes following partial nephrectomy and radiofrequency ablation

Authors
 Faddegon Stephen  ;  Ju Tom  ;  Olweny O. Ephrem  ;  Liu Zhuowei  ;  Han K. Woong  ;  Yin Gang  ;  Tan K. Yung  ;  Gahan Jeffrey  ;  Bedir Selahattin  ;  Ma Yun-Bo  ;  Park K. Samuel  ;  Raj V. Ganesh  ;  Cadeddu A. Jeffrey 
Citation
 CANADIAN JOURNAL OF UROLOGY, Vol.20(3) : 6785-6789, 2013 
Journal Title
CANADIAN JOURNAL OF UROLOGY
ISSN
 1195-9479 
Issue Date
2013
MeSH
Adult ; Aged ; CatheterAblation/methods* ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Filtration Rate/physiology ; Humans ; Incidence ; Kaplan-Meier Estimate ; Kidney/physiopathology* ; Kidney/surgery* ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery* ; Male ; Middle Aged ; Multivariate Analysis ; Nephrectomy/methods* ; RenalInsufficiency, Chronic/epidemiology ; RenalInsufficiency, Chronic/physiopathology ; Retrospective Studies ; Treatment Outcome
Keywords
Adult ; Aged ; CatheterAblation/methods* ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Filtration Rate/physiology ; Humans ; Incidence ; Kaplan-Meier Estimate ; Kidney/physiopathology* ; Kidney/surgery* ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery* ; Male ; Middle Aged ; Multivariate Analysis ; Nephrectomy/methods* ; RenalInsufficiency, Chronic/epidemiology ; RenalInsufficiency, Chronic/physiopathology ; Retrospective Studies ; Treatment Outcome
Abstract
INTRODUCTION: To compare long term glomerular filtration rate (GFR) outcomes of partial nephrectomy and radiofrequency ablation performed for renal malignancy. MATERIALS AND METHODS: Renal function of 347 patients undergoing radiofrequency ablation (n = 142) or partial nephrectomy (n = 205) for renal malignancy between 1994 and 2011 were compared from a retrospective database at a single tertiary care center. Minimum 1 year of follow up was required, resulting in a mean follow up of 48.2 (SD +/- 28.2) months. Renal function was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The primary study outcome was progression of Chronic Kidney Disease (CKD) stage, calculated using the Kaplan-Meier life table method. Multivariate analysis was also conducted to determine the level of association between GFR decline and treatment modality. RESULTS: The 5 year freedom from CKD stage progression for radiofrequency ablation and partial nephrectomy was 85.4% (95% CI 76.8%-91.1%) versus 82.1% (95% CI 73.7%-88.1%) (p = 0.06). A longer follow up interval was associated with greater GFR decline, although hypertension, diabetes, age, and tumor size were not. CONCLUSION: Radiofrequency ablation provides similar long term renal function preservation benefit as partial nephrectomy.
Full Text
http://www.canjurol.com/abstract.php?ArticleID=&version=1.0&PMID=23783048
DOI
23783048
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88215
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