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Characteristics, management of the neck, and oncological outcomes of malignant minor salivary gland tumours in the oral and sinonasal regions.

Authors
 So-Yoon Lee  ;  Hyang Ae Shin  ;  Kyung Jin Rho  ;  Hyo Jin Chung  ;  Se-Heon Kim  ;  Eun Chang Choi 
Citation
 BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, Vol.51(7) : 142-147, 2013 
Journal Title
 BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 
ISSN
 0266-4356 
Issue Date
2013
MeSH
Adult ; Carcinoma, Adenoid Cystic/pathology* ; Carcinoma, Adenoid Cystic/surgery ; Carcinoma, Mucoepidermoid/pathology* ; Carcinoma, Mucoepidermoid/surgery ; Female ; Humans ; Kaplan-Meier Estimate ; Logistic Models ; Male ; Middle Aged ; Neck Dissection ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/prevention & control* ; Neoplasm Recurrence, Local/prevention & control* ; Neoplasm Staging ; Radiotherapy, Adjuvant ; Retrospective Studies ; Salivary Gland Neoplasms/pathology* ; Salivary Gland Neoplasms/surgery ; Salivary Glands, Minor/pathology* ; Salivary Glands, Minor/surgery ; Survival Analysis
Keywords
Malignancy ; Minor salivary gland ; Neck management ; Oral ; Sinonasal tract ; Survival
Abstract
The aim of this study was to evaluate the characteristics of malignant tumours of the minor salivary glands in the oral and sinonasal regions, to make sure that the neck was managed correctly, and to identify oncological outcomes, retrospectively, at a single hospital. A total of 60 patients were reviewed. Forty-nine patients had intraoral lesions and 11 had sinonasal lesions. Of the 60 patients, 28 had stage I to II malignant tumours, and 32 had stage III to IV tumours. Treatment was almost exclusively surgical. One of the 16 patients whose nodes were clinically clear had an elective neck dissection. Adjuvant radiotherapy was given if indicated. The mean follow-up period was 52 months (range 13–190). Sinonasal lesions were all advanced T-stage at diagnosis, had more invaded resection margins, and a higher local recurrence rate than intraoral lesions. There was no regional recurrence in those patients whose nodes were clinically invaded and who had therapeutic neck dissection, or in the patient whose nodes were clinically clear and who had an elective neck dissection. Occult metastases developed exclusively in adenoid cystic carcinomas (ACC), the rate of which was 4/16. Regional recurrence developed in 4 patients who had never had elective treatment to the neck 2 of whom mixed pattern ACC and 2 who had low grade mucoepidermoid carcinomas (MEC). The overall survival was 90% at 2 years, 77% at 5 years, and 74% at 10 years. Sinonasal minor salivary gland tumours require careful follow-up because resection margins are more likely to be invaded by tumour, and they have a higher local recurrence rate than intraoral lesions. Elective neck dissection is needed, particularly for MEC and also to prevent regional recurrence in ACC.
Full Text
http://www.sciencedirect.com/science/article/pii/S0266435612004159
DOI
10.1016/j.bjoms.2012.05.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Heon(김세헌)
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88146
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