Cited 41 times in
Effect of Propofol Post-treatment on Blood-Brain Barrier Integrity and Cerebral Edema After Transient Cerebral Ischemia in Rats.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 김정민 | - |
dc.contributor.author | 신서경 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 이종은 | - |
dc.date.accessioned | 2014-12-18T09:24:40Z | - |
dc.date.available | 2014-12-18T09:24:40Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88119 | - |
dc.description.abstract | Although propofol has been reported to offer neuroprotection against cerebral ischemia injury, its impact on cerebral edema following ischemia is not clear. The objective of this investigation is to evaluate the effects of propofol post-treatment on blood–brain barrier (BBB) integrity and cerebral edema after transient cerebral ischemia and its mechanism of action, focusing on modulation of aquaporins (AQPs), matrix metalloproteinases (MMPs), and hypoxia inducible factor (HIF)-1α. Cerebral ischemia was induced in male Sprague–Dawley rats (n = 78) by occlusion of the right middle cerebral artery for 1 h. For post-treatment with propofol, 1 mg kg−1 min−1 of propofol was administered for 1 h from the start of reperfusion. Nineteen rats undergoing sham surgery were also included in the investigation. Edema and BBB integrity were assessed by quantification of cerebral water content and extravasation of Evans blue, respectively, following 24 h of reperfusion. In addition, the expression of AQP-1, AQP-4, MMP-2, and MMP-9 was determined 24 h after reperfusion and the expression of HIF-1α was determined 8 h after reperfusion. Propofol post-treatment significantly reduced cerebral edema (P < 0.05) and BBB disruption (P < 0.05) compared with the saline-treated control. The expression of AQP-1, AQP-4, MMP-2, and MMP-9 at 24 h and of HIF-1α at 8 h following ischemia/reperfusion was significantly suppressed in the propofol post-treatment group (P < 0.05). Propofol post-treatment attenuated cerebral edema after transient cerebral ischemia, in association with reduced expression of AQP-1, AQP-4, MMP-2, and MMP-9. The decreased expression of AQPs and MMPs after propofol post-treatment might result from suppression of HIF-1α expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NEUROCHEMICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aquaporin 1/biosynthesis | - |
dc.subject.MESH | Aquaporin 4/biosynthesis | - |
dc.subject.MESH | Blood-Brain Barrier/drug effects* | - |
dc.subject.MESH | Brain Edema/prevention & control* | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis | - |
dc.subject.MESH | Infarction, Middle Cerebral Artery/physiopathology | - |
dc.subject.MESH | Ischemic Attack, Transient/physiopathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 2/biosynthesis | - |
dc.subject.MESH | Matrix Metalloproteinase 9/biosynthesis | - |
dc.subject.MESH | Propofol/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Effect of Propofol Post-treatment on Blood-Brain Barrier Integrity and Cerebral Edema After Transient Cerebral Ischemia in Rats. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Hui Song Cui | - |
dc.contributor.googleauthor | Seo Kyung Shin | - |
dc.contributor.googleauthor | Jeong Min Kim | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.1007/s11064-013-1136-7 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00884 | - |
dc.contributor.localId | A02109 | - |
dc.contributor.localId | A03092 | - |
dc.contributor.localId | A03146 | - |
dc.contributor.localId | A00616 | - |
dc.relation.journalcode | J02325 | - |
dc.identifier.eissn | 1573-6903 | - |
dc.identifier.pmid | 23990224 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11064-013-1136-7 | - |
dc.subject.keyword | Blood–brain barrier | - |
dc.subject.keyword | Cerebral edema | - |
dc.subject.keyword | Cerebral ischemia | - |
dc.subject.keyword | Propofol | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Kim, Jeongmin | - |
dc.contributor.alternativeName | Shin, Seo Kyung | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Kim, Jeongmin | - |
dc.contributor.affiliatedAuthor | Shin, Seo Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 38 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2276 | - |
dc.citation.endPage | 2286 | - |
dc.identifier.bibliographicCitation | NEUROCHEMICAL RESEARCH, Vol.38(11) : 2276-2286, 2013 | - |
dc.identifier.rimsid | 33066 | - |
dc.type.rims | ART | - |
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