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Effect of Propofol Post-treatment on Blood-Brain Barrier Integrity and Cerebral Edema After Transient Cerebral Ischemia in Rats.

DC Field Value Language
dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.contributor.author김정민-
dc.contributor.author신서경-
dc.contributor.author이재훈-
dc.contributor.author이종은-
dc.date.accessioned2014-12-18T09:24:40Z-
dc.date.available2014-12-18T09:24:40Z-
dc.date.issued2013-
dc.identifier.issn0364-3190-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88119-
dc.description.abstractAlthough propofol has been reported to offer neuroprotection against cerebral ischemia injury, its impact on cerebral edema following ischemia is not clear. The objective of this investigation is to evaluate the effects of propofol post-treatment on blood–brain barrier (BBB) integrity and cerebral edema after transient cerebral ischemia and its mechanism of action, focusing on modulation of aquaporins (AQPs), matrix metalloproteinases (MMPs), and hypoxia inducible factor (HIF)-1α. Cerebral ischemia was induced in male Sprague–Dawley rats (n = 78) by occlusion of the right middle cerebral artery for 1 h. For post-treatment with propofol, 1 mg kg−1 min−1 of propofol was administered for 1 h from the start of reperfusion. Nineteen rats undergoing sham surgery were also included in the investigation. Edema and BBB integrity were assessed by quantification of cerebral water content and extravasation of Evans blue, respectively, following 24 h of reperfusion. In addition, the expression of AQP-1, AQP-4, MMP-2, and MMP-9 was determined 24 h after reperfusion and the expression of HIF-1α was determined 8 h after reperfusion. Propofol post-treatment significantly reduced cerebral edema (P < 0.05) and BBB disruption (P < 0.05) compared with the saline-treated control. The expression of AQP-1, AQP-4, MMP-2, and MMP-9 at 24 h and of HIF-1α at 8 h following ischemia/reperfusion was significantly suppressed in the propofol post-treatment group (P < 0.05). Propofol post-treatment attenuated cerebral edema after transient cerebral ischemia, in association with reduced expression of AQP-1, AQP-4, MMP-2, and MMP-9. The decreased expression of AQPs and MMPs after propofol post-treatment might result from suppression of HIF-1α expression.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNEUROCHEMICAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAquaporin 1/biosynthesis-
dc.subject.MESHAquaporin 4/biosynthesis-
dc.subject.MESHBlood-Brain Barrier/drug effects*-
dc.subject.MESHBrain Edema/prevention & control*-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit/biosynthesis-
dc.subject.MESHInfarction, Middle Cerebral Artery/physiopathology-
dc.subject.MESHIschemic Attack, Transient/physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 2/biosynthesis-
dc.subject.MESHMatrix Metalloproteinase 9/biosynthesis-
dc.subject.MESHPropofol/pharmacology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.titleEffect of Propofol Post-treatment on Blood-Brain Barrier Integrity and Cerebral Edema After Transient Cerebral Ischemia in Rats.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorHui Song Cui-
dc.contributor.googleauthorSeo Kyung Shin-
dc.contributor.googleauthorJeong Min Kim-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorJong Eun Lee-
dc.contributor.googleauthorBon-Nyeo Koo-
dc.identifier.doi10.1007/s11064-013-1136-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00193-
dc.contributor.localIdA00884-
dc.contributor.localIdA02109-
dc.contributor.localIdA03092-
dc.contributor.localIdA03146-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ02325-
dc.identifier.eissn1573-6903-
dc.identifier.pmid23990224-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs11064-013-1136-7-
dc.subject.keywordBlood–brain barrier-
dc.subject.keywordCerebral edema-
dc.subject.keywordCerebral ischemia-
dc.subject.keywordPropofol-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameKim, Jeongmin-
dc.contributor.alternativeNameShin, Seo Kyung-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.alternativeNameLee, Jong Eun-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.contributor.affiliatedAuthorKim, Jeongmin-
dc.contributor.affiliatedAuthorShin, Seo Kyung-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorLee, Jong Eun-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume38-
dc.citation.number11-
dc.citation.startPage2276-
dc.citation.endPage2286-
dc.identifier.bibliographicCitationNEUROCHEMICAL RESEARCH, Vol.38(11) : 2276-2286, 2013-
dc.identifier.rimsid33066-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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