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Outcomes of Peritonitis in Children on Peritoneal Dialysis: A 25-Year Experience at Severance Hospital

 Kyong Ok Lee  ;  Se Jin Park  ;  Ji Hong Kim  ;  Jae Seung Lee  ;  Pyung Kil Kim  ;  Jae Il Shin 
 YONSEI MEDICAL JOURNAL, Vol.54(4) : 983-989, 2013 
Journal Title
Issue Date
Adolescent ; Anti-Bacterial Agents/therapeutic use ; Cefazolin/therapeutic use ; Ceftazidime/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Peritoneal Dialysis/adverse effects* ; Peritoneal Dialysis/methods ; Peritoneal Dialysis, Continuous Ambulatory/adverse effects* ; Peritonitis/drug therapy ; Peritonitis/epidemiology ; Peritonitis/etiology* ; Peritonitis/microbiology* ; Tobramycin/therapeutic use ; Treatment Outcome
Peritoneal dialysis ; automated peritoneal dialysis ; children ; continuous ambulatory peritoneal dialysis ; peritonitis
PURPOSE: Relatively little is known on the microbiology, risk factors and outcomes of peritoneal dialysis (PD)-associated peritonitis in Korean children. We performed this study in order to evaluate the incidence, treatment and clinical outcomes of peritonitis in pediatric PD patients at Severance Hospital. MATERIALS AND METHODS: We analyzed data from 57 PD patients younger than 18 years during the period between June 1, 1986 and December 31, 2011. The collected data included gender, age at commencement of PD, age at peritonitis, incidence of peritonitis, underlying causes of end stage renal disease, microbiology of peritonitis episodes, antibiotics sensitivity, modality and outcomes of PD. RESULTS: We found 56 episodes of peritonitis in 23 of the 57 PD patients (0.43 episodes/patient-year). Gram-positive bacteria were the most commonly isolated organisms (40 episodes, 71.4%). Peritonitis developed in 17 patients during the first 6 months following initiation of PD (73.9%). Peritonitis episodes rarely resulted in relapse or the need for permanent hemodialysis and no patient deaths were directly attributable to peritonitis. Antibiotic regimens included cefazolin+tobramycin from the years of 1986 to 2000 and cefazolin+ ceftazidime from the years of 2001 to 2011. While antibiotic therapy was successful in 48 episodes (85.7%), the treatment was ineffective in 8 episodes (14.3%). The rate of continuous ambulatory PD (CAPD) peritonitis was statistically higher than that of automated PD (APD) (p=0.025). CONCLUSION: Peritonitis was an important complication of PD therapy and we observed a higher incidence of PD peritonitis in patients with CAPD when compared to APD.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Pyung Kil(김병길)
Kim, Ji Hong(김지홍) ORCID logo https://orcid.org/0000-0001-5352-5423
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Jae Seung(이재승)
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