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Risk Factors of Pulmonary Hypertension in Preterm Infants with Chronic Lung Disease

Other Titles
 만성폐질환을 가진 미숙아에서 폐동맥고혈압증의 위험인자 
 Jeong Jin Ra  ;  Soon Min Lee  ;  Ho Sun Eun  ;  Min Soo Park  ;  Kook In Park  ;  Ran Namgung  ;  Chul Lee 
 Neonatal Medicine, Vol.20(1) : 75-80, 2013 
Journal Title
Neonatal Medicine
Issue Date
Pulmonary hypertension ; Bronchopulmonary dysplasia ; Preterm
Pulmonary hypertension (PH) is known as a major risk factor for preterm infants deaths, and associated with low gestational age, low birth weight, longer duration of oxygen therapy, low Apgar scores, and oligohydramnios. The aim of this study was to determine the risk factors for PH in preterm infants with chronic lung disease.

A retrospective review was performed of data from 86 infants (<32 weeks of gestation) who diagnosed with chronic lung disease at Severance Children's Hospital from July 2006 to June 2011. PH was diagnosed on the basis of echocardiogram demonstrating elevated right ventricle pressure. The infants were divided into two groups: PH group (n=18) or control group (n=67).

PH group showed lower gestational age and underwent longer duration of oxygen therapy, mechanical ventilation, and hospitalization compared with control group. PH group received more surfactant therapy, and the frequency of the development of intraventricular hemorrhage (IVH) (≥G3) and severe chronic lung disease was higher in PH group than control group. According to multivariate analysis, IVH (≥G3) (OR=5.00, 95% CI=1.10-22.63, P=0.037) and severe BPD (OR=2.43, 95% CI=1.03-15.41, P=0.045) were found to be significant risk factors for PH in preterm infants with chronic lung disease.

Pulmonary hypertension was significantly increased in preterm infants with chronic lung disease when associated with IVH (≥G3). We suggest that effort for early diagnosis and management for PH would be helpful in preterm infants with chronic lung disease when severe IVH was combined.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
Lee, Chul(이철)
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