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급성 췌장염의 병태생리

Other Titles
 Pathogenesis of Acute Pancreatitis 
Authors
 오탁근 ; 방승민 
Citation
 Korean Journal of Medicine (대한내과학회지), Vol.85(2) : 111~115, 2013 
Journal Title
 Korean Journal of Medcine (대한내과학회지) 
ISSN
 1738-9364 
Issue Date
2013
Abstract
Acute pancreatitis is an inflammatory disease that is caused by various etiologies including gallstone, alcohol or hypertriglyceridemia. Although most cases of acute pancreatitis show self-limiting course, severe cases are still associated with significant morbidity and mortality. The pathogenic mechanisms of acute pancreatitis are not fully understood. However, it is a central dogma that premature intracellular activation of trypsinogen is the earliest pathologic event. Even though it remains unknown how intracellular trypsinogen activation can be caused by such diverse etiologies, this initial insult in pancreatic acinar cells lead to local inflammatory complications and a systemic response or death. Pathophysiologic mechanisms related to the progression of acute pancreatitis include microcirculatory injury, chemoattraction of inflammatory cells, release of pro-inflammatory cytokines, and bacterial translocation to pancreas and systemic circulation. Recently, several interesting transgenic mice model experiments shed a light in trypsin independent mechanism of local and systemic inflammation for progression of acute pancreatitis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88082
DOI
10.3904/kjm.2013.85.2.111
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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