Cited 17 times in
Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model
DC Field | Value | Language |
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dc.contributor.author | 차민지 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2014-12-18T09:22:42Z | - |
dc.date.available | 2014-12-18T09:22:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88059 | - |
dc.description.abstract | Heat shock proteins, acting as molecular chaperones, protect heart muscle from ischemic injury and offer a potential approach to therapy. Here we describe preparation of an injectable form of heat shock protein 27, fused with a protein transduction domain (TAT-HSP27) and contained in a hybrid system of poly(d,l-lactic-co-glycolic acid) microsphere and alginate hydrogel. By varying the porous structure of the microspheres, the release of TAT-HSP27 from the hybrid system was sustained for two weeks in vitro. The hybrid system containing TAT-HSP27 was intramyocardially injected into a murine myocardial infarction model, and its therapeutic effect was evaluated in vivo. The sustained delivery of TAT-HSP27 substantially suppressed apoptosis in the infarcted site, and improved the ejection fraction, end-systolic volume and maximum pressure development in the heart. Local and sustained delivery of anti-apoptotic proteins such as HSP27 using a hybrid system may present a promising approach to the treatment of ischemic diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF DRUG TARGETING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alginates/chemistry* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Delayed-Action Preparations | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Drug Carriers/chemistry* | - |
dc.subject.MESH | Gene Products, tat/administration & dosage | - |
dc.subject.MESH | Gene Products, tat/pharmacokinetics | - |
dc.subject.MESH | Gene Products, tat/therapeutic use* | - |
dc.subject.MESH | Glucuronic Acid/chemistry | - |
dc.subject.MESH | HSP27 Heat-Shock Proteins/administration & dosage | - |
dc.subject.MESH | HSP27 Heat-Shock Proteins/pharmacokinetics | - |
dc.subject.MESH | HSP27 Heat-Shock Proteins/therapeutic use* | - |
dc.subject.MESH | Hexuronic Acids/chemistry | - |
dc.subject.MESH | Hydrogels | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Lactic Acid/chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microspheres | - |
dc.subject.MESH | Myocardial Infarction/drug therapy* | - |
dc.subject.MESH | Myocardial Infarction/metabolism | - |
dc.subject.MESH | Myocardial Infarction/pathology | - |
dc.subject.MESH | Polyglycolic Acid/chemistry* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recombinant Fusion Proteins/administration & dosage | - |
dc.subject.MESH | Recombinant Fusion Proteins/pharmacokinetics | - |
dc.subject.MESH | Recombinant Fusion Proteins/therapeutic use* | - |
dc.title | Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Jangwook Lee | - |
dc.contributor.googleauthor | Min-Ji Cha | - |
dc.contributor.googleauthor | Kwang Suk Lim | - |
dc.contributor.googleauthor | Jang-Kyung Kim | - |
dc.contributor.googleauthor | Sang-Kyung Lee | - |
dc.contributor.googleauthor | Yong-Hee Kim | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Kuen Yong Lee | - |
dc.identifier.doi | 10.3109/1061186X.2013.829072 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03995 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J01381 | - |
dc.identifier.eissn | 1029-2330 | - |
dc.identifier.pmid | 23952941 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/1061186X.2013.829072 | - |
dc.subject.keyword | Heat shock protein | - |
dc.subject.keyword | microsphere/hydrogel hybrid system | - |
dc.subject.keyword | myocardial infarction | - |
dc.contributor.alternativeName | Cha, Min Ji | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Cha, Min Ji | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 822 | - |
dc.citation.endPage | 829 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DRUG TARGETING, Vol.21(9) : 822-829, 2013 | - |
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