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Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children

 Mi-Ae Oh  ;  Jung Yeon Shim  ;  Young-Ho Jung  ;  Ju-Hee Seo  ;  Hyung Young Kim  ;  Ji-Won Kwon  ;  Byoung-Ju Kim  ;  Hyo Bin Kim  ;  Woo Kyung Kim  ;  So-Yeon Lee  ;  Gwang Cheon Jang  ;  Dae Jin Song  ;  Ha-Jung Kim  ;  Yee-Jin Shin  ;  Jung-Won Park  ;  Sang-Heon Cho  ;  Joo-Shil Lee  ;  Soo-Jong Hong 
 PEDIATRIC PULMONOLOGY, Vol.48(6) : 563-570, 2013 
Journal Title
Issue Date
Asthma/complications ; Asthma/diagnosis ; Asthma/metabolism ; Biomarkers/metabolism ; Bronchial Provocation Tests ; Child ; Child, Preschool ; Cross-Sectional Studies ; Exhalation ; Female ; Humans ; Male ; Nitric Oxide/metabolism* ; Phenotype* ; Respiratory Function Tests ; Respiratory Hypersensitivity/complications ; Respiratory Hypersensitivity/diagnosis ; Respiratory Hypersensitivity/metabolism ; Respiratory Sounds/etiology ; Respiratory Sounds/physiology* ; Skin Tests ; Surveys and Questionnaires
exhaled nitric oxide ; wheezing phenotype ; preschool children ; atopy ; airwayhyperresponsiveness
BACKGROUND: Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. OBJECTIVES: To investigate if FeNO concentrations were correlated with wheezing phenotypes in preschool children and to compare the FeNO results with airway hyperresponsiveness (AHR) and pulmonary function test (PFT) results. METHODS: We performed skin prick tests, methacholine provocation tests, PFT, impulse oscillometry bronchodilator response (IOS BDR) tests, and FeNO measurements in 372 preschool children between the ages of 4 and 6 years. Wheezing phenotypes were defined according to the age of onset and persistency. RESULTS: Persistent wheezers had higher FeNO levels than transient wheezers and non-wheezers. Among persistent wheezers, those with atopy and AHR had significantly higher FeNO levels than those without atopy or AHR. FeNO levels were significantly higher in late-onset wheezers than early-onset wheezers and non-wheezers. Among late-onset wheezers, those with atopy and AHR had a significantly higher FeNO concentration than those without atopy or AHR as well as those with either atopy or AHR. However, there were no significant differences in AHR, PFT, or IOS BDR between persistent and transient wheezers or between late-onset wheezers and early-onset wheezers. CONCLUSION: FeNO may be a better marker for asthma phenotypes in preschool children than AHR and PFT results.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
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