18 60

Cited 4 times in

Impact of family history on the presentation and clinical outcomes of coronary heart disease: data from the Korea Acute Myocardial Infarction Registry

Authors
 Choongki Kim ; Hyuk-Jae Chang ; Yang Soo Jang ; Myung Ho Jeong ; Donghoon Choi ; Ji Min Sung ; Iksung Cho 
Citation
 Korean Journal of Internal Medicine, Vol.28(5) : 547~556, 2013 
Journal Title
 Korean Journal of Internal Medicine 
ISSN
 1226-3303 
Issue Date
2013
Abstract
Background/Aims Family history (FHx) of coronary heart disease (CHD) is a well-known risk factor for CHD. However, the prognostic implication of FHx has not been established clearly in patients with acute myocardial infarction (AMI). Methods In total, 11,612 patients (8,132 males [70%], age 63 ± 13 years) with first-onset AMI between November 2005 and June 2008 in a nationwide, prospective, multicenter, online registry (the Korea AMI Registry) were analyzed. Clinical characteristics and outcomes (cardiac death and major adverse cardiac events [MACEs]) were assessed according to the presence of FHx. Results The patients with FHx were younger and included more males. Male patients with FHx included more current smokers and individuals with poor lipid profiles. In all patients, after adjustment using the Cox proportional hazard model, FHx was related to the risk of MACEs (hazard ratio [HR], 1.41; p = 0.009) and cardiac death (HR, 1.56; p = 0.080). The poor prognostic implication of FHx was further augmented in females and a low risk subset of patients. A significant interaction was only found between male and female patients for composite MACEs (p for interaction = 0.057), and between patients with more risk factors (≥ 2 risk factors) and fewer risk factors for cardiac deaths (p for interaction = 0.008). Conclusions FHx may be an independent prognostic predictor, especially in female patients and patients with low-risk profile.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87988
DOI
10.3904/kjim.2013.28.5.547
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201303324.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse