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Association of urinary sodium/creatinine ratio and urinary sodium/specific gravity unit ratio with blood pressure and hypertension: KNHANES 2009–2010

Authors
 Sang-Guk Lee  ;  Woonhyoung Lee  ;  Oh Hun Kwon  ;  Jeong-Ho Kim 
Citation
 CLINICA CHIMICA ACTA, Vol.424 : 168-173, 2013 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2013
MeSH
Adult ; Aged ; Blood Pressure* ; Creatinine/urine* ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Hypertension/urine* ; Male ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Republic of Korea/epidemiology ; Risk Factors ; Sodium/urine* ; Sodium, Dietary/metabolism* ; Specific Gravity ; Young Adult
Keywords
Blood pressure ; Hypertension ; Urinary sodium/creatinine ratio ; Urinary sodium/specific gravity unit ratio
Abstract
Abstract BACKGROUND: We investigated the association between urinary sodium/creatinine ratio (U[Na(+)]/Cr) or urinary sodium/specific gravity unit ratio (U[Na(+)]/SGU), estimated from spot urine, and blood pressure (BP) and hypertension. METHODS: The study population consisted of a total of 9674 adults (4478 men, 5196 women) who participated in the Korea National Health and Nutrition Examination Surveys conducted in 2009 and 2010. Urine levels of sodium and creatinine, urine specific gravity (SG), and BP were measured along with other risk factors of hypertension. SGU is the calculated parameter of (SG-1)×100. RESULTS: There were significant trends of increasing mean systolic and diastolic BPs and prevalence of hypertension with increasing quartile of U[Na(+)]/Cr and U[Na(+)]/SGU. After adjusting for age, total cholesterol, alcohol drinking, obesity, current smoking, mild renal dysfunction, and diabetes mellitus, the odds ratios (ORs) for hypertension in the top quartile of U[Na(+)]/Cr compared with the bottom quartile were 1.40 in men and 2.68 in women. Similarly, the ORs for hypertension in the top quartile of U[Na(+)]/SGU were 1.29 in men and 3.02 in women after adjustment. CONCLUSIONS: U[Na(+)]/Cr and U[Na(+)]/SGU are associated with BP and hypertension, supporting the possible clinical value of U[Na(+)]/Cr and U[Na(+)]/SGU in general medical facilities.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898113002416
DOI
10.1016/j.cca.2013.05.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Hun(권오헌)
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87984
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