3 780

Cited 12 times in

The association between asymptomatic coronary artery disease and CHADS2 and CHA2DS2-VASc scores in patients with stroke

DC Field Value Language
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author이혜선-
dc.contributor.author차명진-
dc.contributor.author허지회-
dc.date.accessioned2014-12-18T09:19:39Z-
dc.date.available2014-12-18T09:19:39Z-
dc.date.issued2013-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87964-
dc.description.abstractBACKGROUND AND PURPOSE: CHADS2 and CHA2 DS2 -VASc scores are measurement tools that stratify thromboembolic risk in patients with non-valvular atrial fibrillation, and are predictive of cerebral atherosclerosis, fatal stroke and ischaemic heart disease. Patients with higher CHADS2 and CHA2 DS2 -VASc scores are more likely to have had an akinetic/hypokinetic left ventricular segment or a recent myocardial infarction, all of which are associated with coronary artery disease (CAD). Most of the CHADS2 score components are also risk factors for atherosclerosis. Thus, CHADS2 and CHA2 DS2 -VASc scores may be predictive of CAD. METHODS: In all, 1733 consecutive patients with acute ischaemic stroke who underwent multi-slice computed tomography coronary angiography were enrolled. The association of CHADS2 and CHA2 DS2 -VASc scores with the presence and severity of CAD was investigated. RESULTS: Of the 1733 patients, 1220 patients (70.4%) had any degree of CAD and 576 (33.3%) had significant CAD (≥ 50% stenosis in at least one coronary artery). As the CHADS2 and CHA2 DS2 -VASc scores increased, the presence of CAD also increased (P < 0.001). The severity of CAD was correlated with CHADS2 score (Spearman coefficient 0.229, P < 0.001) and CHA2 DS2 -VASc score (Spearman coefficient 0.261, P < 0.001). In multivariate analysis, after adjusting for confounding factors, CHADS2 and CHA2 DS2 -VASc scores ≥2 were independently associated with CAD. The CHA2 DS2 -VASc score was a better predictor of the presence of CAD than the CHADS2 score on area under the curve analysis. CONCLUSION: CHADS2 and CHA2 DS2 -VASc scores were predictive of the presence and severity of CAD in patients with stroke. When a patient has high CHADS2 or CHA2 DS2 -VASc scores, physicians should consider coronary artery evaluation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Artery Disease/complications*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests*-
dc.subject.MESHRisk Assessment/methods*-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke/complications*-
dc.titleThe association between asymptomatic coronary artery disease and CHADS2 and CHA2DS2-VASc scores in patients with stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorM.-J. Cha-
dc.contributor.googleauthorH. S. Lee-
dc.contributor.googleauthorY. D. Kim-
dc.contributor.googleauthorH. S. Nam-
dc.contributor.googleauthorJ. H. Heo-
dc.identifier.doi10.1111/ene.12158-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA03993-
dc.contributor.localIdA04369-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid23560528-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ene.12158/abstract-
dc.subject.keywordCHA2DS2-VAScscore-
dc.subject.keywordCHADS2 score-
dc.subject.keywordcoronary artery disease-
dc.subject.keywordstroke-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameCha, Myoung Jin-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorCha, Myoung Jin-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage1256-
dc.citation.endPage1263-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.20(9) : 1256-1263, 2013-
dc.identifier.rimsid33876-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.