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Personalized therapy on the horizon for squamous cell carcinoma of the lung

DC Field Value Language
dc.contributor.author조병철-
dc.contributor.author김한상-
dc.date.accessioned2014-12-18T09:17:24Z-
dc.date.available2014-12-18T09:17:24Z-
dc.date.issued2013-
dc.identifier.issn0169-5002-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87891-
dc.description.abstractSquamous cell carcinoma (SQCC) of the lung is the second-largest subtype of non-small cell lung cancer (NSCLC), causing an estimated 400,000 deaths per year worldwide. Recent developments in cancer genome sequencing technology expanded our knowledge of driver mutations, which were identified as novel candidates for targeted therapy in various cancers. Successful targeted treatments for lung adenocarcinoma, NSCLC's primary subtype, with EGFR mutation or ALK fusion are clinically available, and a clinical trial of personalized targeted therapy in patients with lung adenocarcinoma is underway by the Lung Cancer Mutation Consortium. Although there are targeted treatments for lung adenocarcinoma, no personalized therapies currently exist for SQCC. Recently, comprehensive genomic characterization of lung SQCC using massively parallel sequencing has enabled us to identify several potential driver mutations/signaling pathways. These are FGFR1 amplifications, PI3KCA mutations, PTEN mutations/deletions, PDGFRA amplifications/mutations, and DDR2 mutations. The march toward personalized therapy may have taken a step forward with the discovery of these potential biomarkers for the treatment of SQCC of the lung. This article reviewed the current knowledge of genomic landscape of lung SQCC and summarized ongoing clinical trials of targeted agents for lung SQCC. Also, we will suggest several other actionable mutations with matching drugs that should be investigated in future clinical trials for the personalized treatment of lung SQCC.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLUNG CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/genetics-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/genetics-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/genetics*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHClinical Trials as Topic-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/genetics*-
dc.subject.MESHLung Neoplasms/pathology-
dc.subject.MESHMolecular Targeted Therapy*-
dc.subject.MESHMutation-
dc.subject.MESHPrecision Medicine*-
dc.titlePersonalized therapy on the horizon for squamous cell carcinoma of the lung-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHan Sang Kim-
dc.contributor.googleauthorTetsuya Mitsudomi-
dc.contributor.googleauthorRoss A. Soo-
dc.contributor.googleauthorByoung Chul Cho-
dc.identifier.doi10.1016/j.lungcan.2013.02.015-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03822-
dc.contributor.localIdA01098-
dc.relation.journalcodeJ02174-
dc.identifier.eissn1872-8332-
dc.identifier.pmid23489560-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0169500213000743-
dc.subject.keywordSquamous cell carcinoma-
dc.subject.keywordNon-small cell lung cancer-
dc.subject.keywordTargeted therapy-
dc.subject.keywordDriver mutation-
dc.subject.keywordBiomarker-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameKim, Han Sang-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Han Sang-
dc.rights.accessRightsnot free-
dc.citation.volume80-
dc.citation.number3-
dc.citation.startPage249-
dc.citation.endPage255-
dc.identifier.bibliographicCitationLUNG CANCER, Vol.80(3) : 249-255, 2013-
dc.identifier.rimsid32595-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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