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Predictive factors for pregnancy during the first four intrauterine insemination cycles using gonadotropin

 Young Eun Jeon  ;  Ji Ann Jung  ;  Hye Yeon Kim  ;  Seok Kyo Seo  ;  SiHyun Cho  ;  Young Sik Choi  ;  Byung Seok Lee 
 GYNECOLOGICAL ENDOCRINOLOGY, Vol.29(9) : 834-838, 2013 
Journal Title
Issue Date
Adult ; Clomiphene/therapeutic use ; Female ; Fertility Agents, Female/therapeutic use* ; Gonadotropins/therapeutic use* ; Humans ; Infertility, Female/diagnosis* ; Infertility, Female/therapy* ; Insemination, Artificial* ; Nitriles/therapeutic use ; Ovulation Induction/methods ; Pregnancy ; Pregnancy Rate ; Prognosis ; Retrospective Studies ; Triazoles/therapeutic use
Assisted reproductive technology ; infertility ; ovulation induction ; pregnancy
PURPOSE: Although a variety of factors have been reported as affecting pregnancy rates after intrauterine insemination (IUI), there have been conflicting results on prognostic factors. This study aimed to determine predictive factors for pregnancy in patients undergoing the first four IUI cycles. METHODS: A total of 348 IUI cycles using clomiphene citrate or letrozole combined with gonadotropin, or gonadotropin only were analyzed. Baseline clinical characteristics, variables related to ovulation induction and sperm parameters were compared between pregnant (n = 54) and non-pregnant groups (n = 294). Logistic regression analysis was performed to identify factors that could predict a pregnancy. RESULTS: The overall clinical pregnancy rate was 15.5% (54/348) per cycle and 30.0% (54/180) per couple. During the first four IUI cycles, logistic regression analysis revealed that woman who were 39 years or older (OR: 0.263, 95% CI: 0.076-0.906, p = 0.034), longer duration of infertility (OR: 0.967, 95% CI: 0.942-0.993, p = 0.012), endometriosis (versus unexplained infertility; OR: 0.177, 95% CI: 0.040-0.775, p = 0.022) and endometrial thickness below 7 mm (OR: 0.114, 95% CI: 0.015-0.862, p = 0.035) were unfavorable factors to predict clinical pregnancy. CONCLUSIONS: Women with old age, longer duration of infertility, the presence of endometriosis or thin endometrium in the preovulatory phase may have unfavorable outcomes during the first four IUI cycles.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Jeon, Young Eun(전영은)
Jung, Ji Ann(정지안)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
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