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Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기열 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박찬희 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2014-12-18T09:14:47Z | - |
dc.date.available | 2014-12-18T09:14:47Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87808 | - |
dc.description.abstract | BACKGROUND/AIM: To investigate mechanisms of discrepancy in response to a MEK/ERK inhibitor, U0126, in KRAS- and BRAF-mutant colorectal cancer cells. MATERIALS AND METHODS: Multiparametric flow cytometry was performed on two colon cancer cell lines, HCT116 and HT29. Cells were treated with U0126, and phospho-specific antibodies were used to monitor ERK signaling. RESULTS: HCT116 and HT29 cells were treated with increasing amounts of U0126. The western blot analysis revealed that by increasing the amount of U0126 resulted in inhibition of phospho-ERK, in HCT116 and to a lesser degree in HT29 cells. Microarray profiling identified CYP1A1 and 1A2 overexpression in HT29 cells and that inhibition of CYP1A1 with α-naphthoflavone and furanfylline restored sensitivity to U0126 in HT29 cells. CONCLUSION: Combination of a CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF-mutant colon cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Benzoflavones/pharmacology | - |
dc.subject.MESH | Butadienes/pharmacology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Colonic Neoplasms/drug therapy* | - |
dc.subject.MESH | Colonic Neoplasms/genetics | - |
dc.subject.MESH | Cytochrome P-450 CYP1A1/antagonists & inhibitors* | - |
dc.subject.MESH | Cytochrome P-450 CYP1A1/metabolism | - |
dc.subject.MESH | Cytochrome P-450 CYP1A2/metabolism | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MAP Kinase Signaling System/drug effects | - |
dc.subject.MESH | Nitriles/pharmacology | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/antagonists & inhibitors* | - |
dc.title | Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | SUN MIN LIM | - |
dc.contributor.googleauthor | JEE WON HWANG | - |
dc.contributor.googleauthor | JOONG BAE AHN | - |
dc.contributor.googleauthor | SOO KYUNG BAE | - |
dc.contributor.googleauthor | CHAN HEE PARK | - |
dc.contributor.googleauthor | KI-YEOL KIM | - |
dc.contributor.googleauthor | SUN YOUNG RHA | - |
dc.contributor.googleauthor | HYUN CHEOL CHUNG | - |
dc.contributor.googleauthor | JAE KYUNG ROH | - |
dc.contributor.googleauthor | SANG JOON SHIN | - |
dc.identifier.doi | 23749901 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01712 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 23749901 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/33/6/2499.long | - |
dc.subject.keyword | CYP inhibitor | - |
dc.subject.keyword | Cell signaling | - |
dc.subject.keyword | ERK | - |
dc.subject.keyword | HCT116 | - |
dc.subject.keyword | HT29 | - |
dc.subject.keyword | MEK/ERK inhibitor | - |
dc.subject.keyword | U0126 | - |
dc.subject.keyword | colorectal cancer | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Chan Hee | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Lim, Sun Min | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Park, Chan Hee | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Lim, Sun Min | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2499 | - |
dc.citation.endPage | 2508 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.33(6) : 2499-2508, 2013 | - |
dc.identifier.rimsid | 32283 | - |
dc.type.rims | ART | - |
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