Cited 6 times in

Hoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth

DC Field Value Language
dc.contributor.author김명희-
dc.contributor.author민혜현-
dc.contributor.author이지연-
dc.date.accessioned2014-12-18T09:13:14Z-
dc.date.available2014-12-18T09:13:14Z-
dc.date.issued2013-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87759-
dc.description.abstractThe Hox genes, which are organized into clusters on different chromosomes, are key regulators of embryonic anterior-posterior (A-P) body pattern formation and are expressed at specific times and in specific positions in developing vertebrate embryos. Previously, we have shown that histone methylation patterns are closely correlated with collinear Hox gene expression patterns along the A-P axis of E14.5 mouse embryos. Since histone modification is thought to play a crucial mechanistic role in the highly coordinated pattern of collinear Hox gene expression, we examined the maintenance of the spatial collinear expression pattern of Hoxc genes and the corresponding histone modifications during embryogenesis and in early postnatal mice. Hox expression patterns and histone modifications were analyzed by semi-quantitative RT-PCR and chromatin immunoprecipitation (ChIP)-PCR analyses, respectively. The spatiotemporal expression patterns of Hoxc genes in a cluster were maintained until the early postnatal stage (from E8.5 through P5). Examination of histone modifications in E14.5 and P5 tissues revealed that level of H3K27me3 is only a weak correlation with collinear Hoxc gene expression in the trunk regions although diminished in general, however the enrichment of H3K4me3 is strongly correlated with the gene expression in both stages. In summary, the initial spatiotemporal collinear expression pattern of Hoxc genes and epigenetic modifications are maintained after birth, likely contributing to the establishment of the gene expression code for position in the anatomic body axis throughout the entire life of the organism.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBody Patterning/genetics-
dc.subject.MESHChromatin Assembly and Disassembly-
dc.subject.MESHChromatin Immunoprecipitation-
dc.subject.MESHEmbryonic Development/genetics-
dc.subject.MESHEpigenesis, Genetic*-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHGene Expression Regulation, Developmental*-
dc.subject.MESHGenes, Homeobox/physiology*-
dc.subject.MESHHistones/chemistry-
dc.subject.MESHHistones/metabolism*-
dc.subject.MESHMethylation-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.titleHoxc Gene Collinear Expression and Epigenetic Modifications Established during Embryogenesis Are Maintained until after Birth-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorHyehyun Min-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi10.7150/ijbs.6739-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00432-
dc.contributor.localIdA01416-
dc.contributor.localIdA03194-
dc.relation.journalcodeJ01091-
dc.identifier.eissn1449-2288-
dc.identifier.pmid24155669-
dc.subject.keywordHoxc cluster genes-
dc.subject.keywordcollinear expression: anterior-posterior body axis-
dc.subject.keywordhistone modification.-
dc.subject.keywordmouse embryogenesis-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNameMin, Hye Hyun-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.affiliatedAuthorKim, Myoung Hee-
dc.contributor.affiliatedAuthorMin, Hye Hyun-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.rights.accessRightsfree-
dc.citation.volume9-
dc.citation.number9-
dc.citation.startPage960-
dc.citation.endPage965-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, Vol.9(9) : 960-965, 2013-
dc.identifier.rimsid32255-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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