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EGFR and TTF-1 Gene Amplification in Surgically Resected Lung Adenocarcinomas: Clinicopathologic Significance and Effect on Response to EGFR-Tyrosine Kinase Inhibitors in Recurred Cases

DC FieldValueLanguage
dc.contributor.author김혜련-
dc.contributor.author신미화-
dc.contributor.author심효섭-
dc.contributor.author이재석-
dc.contributor.author이창영-
dc.date.accessioned2014-12-18T09:09:42Z-
dc.date.available2014-12-18T09:09:42Z-
dc.date.issued2013-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87648-
dc.description.abstractBackground Gene amplifications are implicated in cancer development and progression. In this study we investigated the clinicopathologic characteristics associated with EGFR or TTF-1 amplification in lung adenocarcinomas and its prognostic significance. Methods We analyzed 118 cases of surgically resected primary lung adenocarcinomas. Amplification of the EGFR or TTF-1 gene was evaluated by fluorescence in situ hybridization and correlated with patients’ clinicopathologic features, including disease-free survival (DFS) and overall survival (OS), in all patients and a subset that were TTF-1 positive or had EGFR mutation. Progression-free survival (PFS) also was analyzed among patients with EGFR mutation who had recurred cancer that was treated with EGFR tyrosine kinase inhibitors. Results EGFR or TTF-1 gene amplification was an independent poor prognostic factor for DFS in all patients (p = 0.001), in patients with TTF-1 positivity (p = 0.010), and in patients with EGFR mutation (p < 0.001) and for OS in patients with TTF-1 positivity (p = 0.021) and patients with EGFR mutation (p < 0.001). Patients with TTF-1 amplification had a shorter PFS following EGFR TKI treatment (p = 0.040). Conclusions EGFR or TTF-1 gene amplification was a predictive factor for poor prognosis in terms of DFS and OS, especially in patients with TTF-1 positivity or EGFR mutation. Our results also suggested that TTF-1 amplification might be a predictive marker of poor response to EGFR-TKI therapy in patients with recurrent tumor after surgical resection.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEGFR and TTF-1 Gene Amplification in Surgically Resected Lung Adenocarcinomas: Clinicopathologic Significance and Effect on Response to EGFR-Tyrosine Kinase Inhibitors in Recurred Cases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJae Seok Lee-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorMihwa Shin-
dc.contributor.googleauthorHyo Sup Shim-
dc.identifier.doi10.1245/s10434-013-2937-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01166-
dc.contributor.localIdA02102-
dc.contributor.localIdA02219-
dc.contributor.localIdA03245-
dc.contributor.localIdA03072-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmidOverall Survival ; Epidermal Growth Factor Receptor ; Epidermal Growth Factor Receptor Mutation ; Anaplastic Lymphoma Kinase ; Bacterial Artificial Chromosome Clone-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-013-2937-2-
dc.subject.keywordOverall Survival-
dc.subject.keywordEpidermal Growth Factor Receptor-
dc.subject.keywordEpidermal Growth Factor Receptor Mutation-
dc.subject.keywordAnaplastic Lymphoma Kinase-
dc.subject.keywordBacterial Artificial Chromosome Clone-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNameShin, Mi Hwa-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameLee, Jae Seok-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorShin, Mi Hwa-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorLee, Jae Seok-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage3015-
dc.citation.endPage3022-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.20(9) : 3015-3022, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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