Cited 6 times in
Effect of Subdermal 1,444-nm Pulsed Neodymium-Doped Yttrium Aluminum Garnet Laser on the Nasolabial Folds and Cheek Laxity
DC Field | Value | Language |
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dc.contributor.author | 노미령 | - |
dc.contributor.author | 정기양 | - |
dc.contributor.author | 지현정 | - |
dc.date.accessioned | 2014-12-18T09:09:20Z | - |
dc.date.available | 2014-12-18T09:09:20Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1076-0512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87636 | - |
dc.description.abstract | BACKGROUND: Wrinkle formation usually accompanies skin aging. In particular, accentuated nasolabial folds and loss of elasticity are early signs of skin aging. The use of 1,444-nm pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers has increased in popularity. OBJECTIVE: To evaluate the safety and efficacy of a novel 1,444-nm pulsed Nd:YAG laser in the treatment of NLF and cheek laxity using subdermal laser therapy. METHODS: Ten Korean patients with moderate to severe NLF were enrolled. Each received a single treatment session with a 1,444-nm Nd:YAG laser. Two blinded physicians evaluated clinical improvement by rating comparative photographs on a 5-point scale. Efficacy was also assessed by measuring elasticity and roughness. Skin biopsies were performed on five volunteers before treatment and 3 months after treatment. RESULTS: The 1,444-nm Nd:YAG laser effectively promoted clinical improvement of NLF and cheek laxity (p < .05). Significant differences in elasticity and roughness were observed (p < .05). Epidermal proliferation was stimulated as demonstrated by increases in epidermal thickness and Ki-67 expression (p < .05). Quantitative image analyses of pre- and post-treatment biopsies revealed that collagen fibers increased from baseline (p > .05). Transforming growth factor beta and heat shock protein-70 messenger RNA levels quantified using real-time reverse transcriptase polymerase chain reaction increased significantly from baseline (p < .05). CONCLUSION: The 1,444-nm Nd:YAG laser is an effective treatment modality with minimal complications for the treatment of NLF and cheek laxity, but further research with a larger group of patients is needed to confirm these findings. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DERMATOLOGIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of Subdermal 1,444-nm Pulsed Neodymium-Doped Yttrium Aluminum Garnet Laser on the Nasolabial Folds and Cheek Laxity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Soo Hyun Lee | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Jin Young Jung | - |
dc.contributor.googleauthor | Hyunjoong Jee | - |
dc.contributor.googleauthor | Kyoung Ae Nam | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.identifier.doi | 10.1111/dsu.12183 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A03582 | - |
dc.contributor.localId | A03972 | - |
dc.relation.journalcode | J00707 | - |
dc.identifier.eissn | 1524-4725 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/dsu.12183/abstract | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.alternativeName | Chung, Kee Yang | - |
dc.contributor.alternativeName | Jee, Hyun Joong | - |
dc.contributor.affiliatedAuthor | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | Chung, Kee Yang | - |
dc.contributor.affiliatedAuthor | Jee, Hyun Joong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1067 | - |
dc.citation.endPage | 1078 | - |
dc.identifier.bibliographicCitation | DERMATOLOGIC SURGERY, Vol.39(7) : 1067-1078, 2013 | - |
dc.identifier.rimsid | 32179 | - |
dc.type.rims | ART | - |
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