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Prediction of Sustained Virologic Response Based on Week 4 and Week 12 Response in Hepatitis C Virus Genotype 1 Patients Treated with Peginterferon and Ribavirin: Assessment in a Favorable IL28B Allele-Prevalent Area

Authors
 Chung H.J.  ;  Lee J.-W.  ;  Kim Y.S.  ;  Lee J.I. 
Citation
 INTERVIROLOGY, Vol.56(3) : 178-183, 2013 
Journal Title
 INTERVIROLOGY 
ISSN
 0300-5526 
Issue Date
2013
MeSH
Adult ; Aged ; Antiviral Agents/therapeutic use* ; Drug Therapy, Combination/methods ; Female ; Genotype ; Hepacivirus/genetics ; Hepacivirus/isolation & purification* ; Hepatitis B, Chronic/drug therapy* ; Hepatitis B, Chronic/virology ; Humans ; Interferon-alpha/therapeutic use* ; Interleukins/genetics ; Male ; Middle Aged ; Polyethylene Glycols/therapeutic use* ; Polymorphism, Genetic ; Predictive Value of Tests ; Prognosis ; Recombinant Proteins/therapeutic use ; Ribavirin/therapeutic use* ; Treatment Outcome ; Viral Load*
Keywords
Adult ; Aged ; Antiviral Agents/therapeutic use* ; Drug Therapy, Combination/methods ; Female ; Genotype ; Hepacivirus/genetics ; Hepacivirus/isolation & purification* ; Hepatitis B, Chronic/drug therapy* ; Hepatitis B, Chronic/virology ; Humans ; Interferon-alpha/therapeutic use* ; Interleukins/genetics ; Male ; Middle Aged ; Polyethylene Glycols/therapeutic use* ; Polymorphism, Genetic ; Predictive Value of Tests ; Prognosis ; Recombinant Proteins/therapeutic use ; Ribavirin/therapeutic use* ; Treatment Outcome ; Viral Load*
Abstract
OBJECTIVES: The aim of this study was to evaluate rapid virologic response (RVR) rate after peginterferon (PegIFN) and ribavirin (RBV) dual combination therapy in Korean hepatitis C virus (HCV) genotype 1 patients whose IL28B polymorphism is generally favorable. This study also assessed the value of RVR in predicting sustained virologic response (SVR). METHODS: Treatment-naïve HCV genotype 1 patients who underwent initial treatment with either PegIFN-α-2a or α-2b and RBV were retrospectively evaluated. From 148 patients, 115 met inclusion criteria for the final analysis. RESULTS: Overall RVR rate was 47.8% and SVR rate was 67.8% (78/115). Positive RVR had the highest positive predictive value (PPV) for achieving SVR, whereas it had the lowest negative predictive value (NPV). Undetectable HCV RNA at treatment week 12, namely complete early virologic response (cEVR), had high PPV as well as high NPV. Factors predisposing SVR were absence of liver cirrhosis and achievement of RVR or cEVR. CONCLUSION: This study showed RVR rate close to 50% in HCV genotype 1 patients treated with dual combination therapy in the region where favorable IL28B polymorphism is reported to be as high as 90%. Even for the patients who failed to achieve RVR, positive cEVR demonstrated a fair chance of achieving SVR.
Full Text
http://www.karger.com/Article/FullText/345539
DOI
10.1159/000345539
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jung Il(이정일) ORCID logo https://orcid.org/0000-0002-0142-1398
Chung, Hyun Jung(정현정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87506
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