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Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain

DC FieldValueLanguage
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author이혁-
dc.contributor.author이현직-
dc.contributor.author김지은-
dc.contributor.author박세우-
dc.date.accessioned2014-12-18T09:05:06Z-
dc.date.available2014-12-18T09:05:06Z-
dc.date.issued2013-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87504-
dc.description.abstractAIM: To investigate the efficacy of amitriptyline with proton pump inhibitor (PPI) for the treatment of functional chest pain (FCP). METHODS: This was a randomized, open-label trial investigating the addition of low dose amitriptyline (10 mg at bedtime) to a conventional dose of rabeprazole (20 mg/d) (group A, n = 20) vs a double-dose of rabeprazole (20 mg twice daily) (group B, n = 20) for patients with FCP whose symptoms were refractory to PPI. The primary efficacy endpoints were assessed by global symptom score assessment and the total number of individuals with > 50% improvement in their symptom score. RESULTS: The between-group difference in global symptom scores was statistically significant during the last week of treatment (overall mean difference; 3.75 ± 0.31 vs 4.35 ± 0.29, the between-group difference; P < 0.001). Furthermore, 70.6% of patients in group A had their symptoms improve by > 50%, whereas only 26.3% of patients in group B had a similar treatment response (70.6% vs 26.3%, P = 0.008). Specifically, patients in group A had a significantly greater improvement in the domains of body pain and general health perception than did patients in group B (52.37 ± 17.00 vs 41.32 ± 12.34, P = 0.031 and 47.95 ± 18.58 vs 31.84 ± 16.84, P = 0.01, respectively). CONCLUSION: Adding amitriptyline to a PPI was more effective than a double-dose of PPI in patients with FCP refractory to a conventional dose of PPI.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenergic Uptake Inhibitors/administration & dosage*-
dc.subject.MESHAdult-
dc.subject.MESHAmitriptyline/administration & dosage*-
dc.subject.MESHChest Pain/diagnosis-
dc.subject.MESHChest Pain/drug therapy*-
dc.subject.MESHChest Pain/etiology-
dc.subject.MESHChest Pain/psychology-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement-
dc.subject.MESHProspective Studies-
dc.subject.MESHProton Pump Inhibitors/administration & dosage*-
dc.subject.MESHQuality of Life-
dc.subject.MESHRabeprazole/administration & dosage*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleLow-dose amitriptyline combined with proton pump inhibitor for functional chest pain-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentMedical Research Center (임상의학연구센터)-
dc.contributor.googleauthorSe Woo Park-
dc.contributor.googleauthorHyuk Lee-
dc.contributor.googleauthorHyun Jik Lee-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorSang Kil Lee-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorJi Eun Kim-
dc.identifier.doi10.3748/wjg.v19.i30.4958-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03285-
dc.contributor.localIdA03300-
dc.contributor.localIdA01520-
dc.contributor.localIdA00993-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid23946601-
dc.subject.keywordAmitriptyline-
dc.subject.keywordFunctional chest pain-
dc.subject.keywordProton pump inhibitor-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameLee, Hyun Jik-
dc.contributor.alternativeNameKim, Ji Eun-
dc.contributor.alternativeNamePark, Se Woo-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.contributor.affiliatedAuthorLee, Hyun Jik-
dc.contributor.affiliatedAuthorPark, Se Woo-
dc.contributor.affiliatedAuthorKim, Ji Eun-
dc.rights.accessRightsfree-
dc.citation.volume19-
dc.citation.number30-
dc.citation.startPage4958-
dc.citation.endPage4965-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.19(30) : 4958-4965, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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