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Amphetamine dephosphorylates ERM proteins in the nucleus accumbens core and lithium attenuates its effects

Authors
 Wha Young Kim ; Ju Kyong Jang ; Jeong-Hoon Kim ; Joong-Keun Shin 
Citation
 Neuroscience Letters, Vol.552 : 103~107, 2013 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2013
Abstract
The ezrin–radixin–moesin (ERM) proteins have been implicated not only in cell-shape determination but also in cellular signaling pathway. We have previously shown that cocaine decreases phosphorylation levels of these proteins in the nucleus accumbens (NAcc), an important brain area mediating addictive behaviors. Here we further revealed that the phosphorylation levels of ERM were decreased in the NAcc core, but not in the shell, by a single injection of amphetamine (AMPH) (2 mg/kg, IP). When lithium (100 mg/kg, IP) was co-administered with AMPH, the decreases of phosphorylation levels for ERM by AMPH were recovered back to basal levels in the NAcc core. Together, these results suggest that psychomotor stimulants like AMPH regulate phosphorylation levels of ERM in the NAcc core and lithium-involved signaling pathway has a regulatory role in the opposite direction in this site.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87408
DOI
10.1016/j.neulet.2013.07.037
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304394013006836
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