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Therapeutic Effect of Oncolytic Adenovirus Expressing Relaxin in Radioresistant Oral Squamous Cell Carcinoma

DC FieldValueLanguage
dc.contributor.author김세헌-
dc.contributor.author박영민-
dc.contributor.author박행란-
dc.date.accessioned2014-12-18T09:01:37Z-
dc.date.available2014-12-18T09:01:37Z-
dc.date.issued2013-
dc.identifier.issn0965-0407-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87393-
dc.description.abstractRadioresistance is one of the main determinants of treatment outcome in oral squamous cell carcinoma (OSCC), and treatment of radioresistant OSCC is difficult due to cross resistance to other conventional treatments. We aimed to identify whether genetically modified oncolytic adenovirus expressing relaxin (RLX), which affects collagen metabolism, can effectively inhibit growth of the radioresistant OSCC. Therapeutic effect of oncolytic adenovirus was compared between radiosensitive and radioresistant OSCC cell lines in vitro and in vivo, and spread of adenovirus throughout the tumor mass was verified by immunohistochemistry (IHC). Oncolytic adenovirus effectively killed cancer cells and there was no significant difference in the cytotoxic effect between radiosensitive and radioresistant OSCC cell lines. In animal experiments, the adenovirus significantly reduced the size of tumor, and there was no significant difference between radiosensitive and radioresistant OSCC. In IHC, RLX expressing adenovirus showed better proliferation and eliminated collagens more effectively compared to RLX nonexpressing adenovirus. These findings suggested that genetically modified oncolytic adenovirus can effectively inhibit growth of the radioresistant OSCC and might be a new therapeutic option in radioresistant OSCC.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfONCOLOGY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoviridae/genetics-
dc.subject.MESHAdenoviridae/physiology*-
dc.subject.MESHAnimals-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCarcinoma, Squamous Cell/secondary-
dc.subject.MESHCell Line, Tumor/radiation effects*-
dc.subject.MESHCell Line, Tumor/virology-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Therapy*-
dc.subject.MESHGenetic Vectors/physiology*-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHMouth Neoplasms/pathology*-
dc.subject.MESHMutagenesis, Site-Directed-
dc.subject.MESHOncolytic Virotherapy*-
dc.subject.MESHOncolytic Viruses/genetics-
dc.subject.MESHOncolytic Viruses/physiology*-
dc.subject.MESHRadiation Tolerance-
dc.subject.MESHRelaxin/genetics-
dc.subject.MESHRelaxin/physiology*-
dc.subject.MESHSpecific Pathogen-Free Organisms-
dc.subject.MESHTongue Neoplasms/pathology-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.titleTherapeutic Effect of Oncolytic Adenovirus Expressing Relaxin in Radioresistant Oral Squamous Cell Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorLee, Sei Young-
dc.contributor.googleauthorPark, Haeng Ran-
dc.contributor.googleauthorRhee, Junghoon-
dc.contributor.googleauthorPark, Young Min-
dc.contributor.googleauthorKim, Se-Heon-
dc.identifier.doi10.3727/096504013X13657689383139-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00605-
dc.contributor.localIdA01566-
dc.contributor.localIdA01731-
dc.relation.journalcodeJ02420-
dc.identifier.eissn1555-3906-
dc.identifier.pmid23924926-
dc.identifier.urlhttp://www.ingentaconnect.com/content/cog/or/2012/00000020/00000009/art00005?token=00531ed3e38ce7f208b0e567232d45232b45246c7b383b746656486b3568293c62207d673f582f6bec1-
dc.subject.keywordAdenovirus-
dc.subject.keywordOral cancer-
dc.subject.keywordOral squamous cell carcinoma (OSCC)-
dc.subject.keywordRadioresistance-
dc.subject.keywordRelaxin (RLX)-
dc.contributor.alternativeNameKim, Se Heon-
dc.contributor.alternativeNamePark, Young Min-
dc.contributor.alternativeNamePark, Haeng Ran-
dc.contributor.affiliatedAuthorKim, Se Heon-
dc.contributor.affiliatedAuthorPark, Young Min-
dc.contributor.affiliatedAuthorPark, Haeng Ran-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage419-
dc.citation.endPage425-
dc.identifier.bibliographicCitationONCOLOGY RESEARCH, Vol.20(9) : 419-425, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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