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Serum IgA reactivity against GroEL of Streptococcus sanguinis and human heterogeneous nuclear ribonucleoprotein A2/B1 in patients with Behçet disease

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author방동식-
dc.contributor.author정진룡-
dc.contributor.author조성빈-
dc.contributor.author조수현-
dc.date.accessioned2014-12-18T08:59:41Z-
dc.date.available2014-12-18T08:59:41Z-
dc.date.issued2013-
dc.identifier.issn0007-0963-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87337-
dc.description.abstractBACKGROUND: Infectious agents, especially Streptococcus sanguinis and herpes simplex virus, have long been postulated as major triggering factors for Behçet disease (BD). OBJECTIVES: To identify an anti-S. sanguinis antigen reacting with serum IgA antibody in patients with BD. METHODS: We detected a target protein by proteomics analysis and evaluated serum IgA reactivity of 100 patients with BD against the identified streptococcal target protein and human heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1. Homologous epitope sequences between the streptococcal target protein and human hnRNP A2/B1 were also evaluated. RESULTS: Four protein bands were detected by immunoprecipitation, and chaperonin GroEL was identified by a proteomics analysis. Reactivity of serum IgA against recombinant S. sanguinis GroEL was detected in 77 of 100 patients with BD (77%) and in 21 of 70 healthy controls (30%). In addition, reactivity of serum IgA against human recombinant hnRNP A2/B1 was seen in 79 of 100 patients with BD (79%) and in eight of 70 healthy controls (11%). Among the eight distinctive epitopes with significant homology between S. sanguinis GroEL and human hnRNP A2/B1, the serum IgA reactivity of patients with BD was markedly higher with epitope 3 (hnRNP A2/B1 peptide 33-46 and GroEL peptide 57-70) and epitope 6 (hnRNP A2/B1 peptide 177-188 and GroEL peptide 347-358). CONCLUSION: We identified an S. sanguinis GroEL protein as a target of serum anti-S. sanguinis IgA antibody reactivity in patients with BD. In addition, patients with BD exhibited serum IgA reactivity against homologous epitope regions between S. sanguinis GroEL and human hnRNP A2/B1.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBRITISH JOURNAL OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBacterial Proteins/immunology*-
dc.subject.MESHBehcet Syndrome/etiology-
dc.subject.MESHBehcet Syndrome/immunology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChaperonin 60/immunology*-
dc.subject.MESHEpitopes/immunology-
dc.subject.MESHFemale-
dc.subject.MESHHeterogeneous-Nuclear Ribonucleoprotein Group A-B/immunology*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin A/blood*-
dc.subject.MESHImmunoprecipitation/methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHStreptococcus sanguis/immunology*-
dc.titleSerum IgA reactivity against GroEL of Streptococcus sanguinis and human heterogeneous nuclear ribonucleoprotein A2/B1 in patients with Behçet disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorS.B. Cho-
dc.contributor.googleauthorZ. Zheng-
dc.contributor.googleauthorK.J. Ahn-
dc.contributor.googleauthorM.J. Choi-
dc.contributor.googleauthorS. Cho-
dc.contributor.googleauthorD.-Y. Kim-
dc.contributor.googleauthorH.S. Lee-
dc.contributor.googleauthorD. Bang-
dc.identifier.doi10.1111/bjd.12128-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.contributor.localIdA03741-
dc.contributor.localIdA03832-
dc.contributor.localIdA03842-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00408-
dc.identifier.eissn1365-2133-
dc.identifier.pmid23137016-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/bjd.12128/abstract-
dc.subject.keywordAdult-
dc.subject.keywordBacterial Proteins/immunology*-
dc.subject.keywordBehcet Syndrome/etiology-
dc.subject.keywordBehcet Syndrome/immunology*-
dc.subject.keywordCase-Control Studies-
dc.subject.keywordChaperonin 60/immunology*-
dc.subject.keywordEpitopes/immunology-
dc.subject.keywordFemale-
dc.subject.keywordHeterogeneous-Nuclear Ribonucleoprotein Group A-B/immunology*-
dc.subject.keywordHumans-
dc.subject.keywordImmunoglobulin A/blood*-
dc.subject.keywordImmunoprecipitation/methods-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordStreptococcus sanguis/immunology*-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.alternativeNameZheng, Zhen Long-
dc.contributor.alternativeNameCho, Sung Bin-
dc.contributor.alternativeNameCho, Su Hyun-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.contributor.affiliatedAuthorZheng, Zhen Long-
dc.contributor.affiliatedAuthorCho, Sung Bin-
dc.contributor.affiliatedAuthorCho, Su Hyun-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsnot free-
dc.citation.volume168-
dc.citation.number5-
dc.citation.startPage977-
dc.citation.endPage983-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF DERMATOLOGY, Vol.168(5) : 977-983, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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