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Prognosis of choroidal melanoma and the result of ruthenium brachytherapy combined with transpupillary thermotherapy in Korean patients

DC FieldValueLanguage
dc.contributor.author권희정-
dc.contributor.author김민-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.date.accessioned2014-12-18T08:58:25Z-
dc.date.available2014-12-18T08:58:25Z-
dc.date.issued2013-
dc.identifier.issn0007-1161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87297-
dc.description.abstractBACKGROUND/AIMS: To evaluate the clinical features and prognosis of choroidal melanoma in Korean patients and the results of treatment with ruthenium (Ru) 106 plaque brachytherapy. METHODS: The medical charts of 111 patients diagnosed with choroidal melanoma who underwent Ru brachytherapy with trans-pupillary thermotherapy or local resection (61 patients) or who underwent other treatments (26 primary enucleations, 22 γ-knife radiotherapies and two lamellar sclerouvectomies) were reviewed retrospectively. RESULTS: The mean largest basal diameter (LBD) was 11.4±3.2 mm and the mean apical height was 7.8±2.9 mm. Compared with the collaborative ocular melanoma study, mean tumour height was skewed toward higher values (6.2 vs 4.8 in medium tumours, p<0.0001; 10.9 vs 9.5 mm in large tumours, p=0.034) and the LBD in large tumours was skewed toward smaller values (13.6 vs 17.3, p<0.0001). The estimated 5-year metastasis-free rate was 73.9% and the disease-specific survival rate was 84.6%. For the 61 patients that were treated with Ru brachytherapy, the 5-year metastasis-free and disease-specific survival rates were 79.0% and 87.7%, respectively, and the 5-year incidence of enucleation was 25.4%. The mean tumour regression at 6, 12 and 18 months after brachytherapy was 80.2%, 73.1% and 69.2%, respectively. CONCLUSIONS: Choroidal melanomas in Korean patients tend to grow vertically with a relatively large apical height and a small LBD. The prognosis of choroidal melanomas overall as well as prognosis after Ru brachytherapy were similar to those seen in previous studies with Caucasian patients. The enucleation rate after brachytherapy seems to be higher in Korean patients, for which a greater initial tumour height seems to be partly responsible.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBRITISH JOURNAL OF OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAsian Continental Ancestry Group/ethnology-
dc.subject.MESHBrachytherapy*-
dc.subject.MESHChoroid Neoplasms/diagnosis*-
dc.subject.MESHChoroid Neoplasms/ethnology-
dc.subject.MESHChoroid Neoplasms/therapy-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEye Enucleation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperthermia, Induced*-
dc.subject.MESHMale-
dc.subject.MESHMelanoma/diagnosis*-
dc.subject.MESHMelanoma/ethnology-
dc.subject.MESHMelanoma/therapy-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHPrognosis-
dc.subject.MESHRadiosurgery-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRuthenium Radioisotopes/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titlePrognosis of choroidal melanoma and the result of ruthenium brachytherapy combined with transpupillary thermotherapy in Korean patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorHee Jung Kwon-
dc.contributor.googleauthorJae Sang Ko-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.contributor.googleauthorSung Chul Lee-
dc.identifier.doi10.1136/bjophthalmol-2012-302584-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00270-
dc.contributor.localIdA00455-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA04876-
dc.relation.journalcodeJ00412-
dc.identifier.eissn1468-2079-
dc.identifier.pmid23428983-
dc.identifier.urlhttp://bjo.bmj.com/content/97/5/653.long-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordAsian Continental Ancestry Group/ethnology-
dc.subject.keywordBrachytherapy*-
dc.subject.keywordChoroid Neoplasms/diagnosis*-
dc.subject.keywordChoroid Neoplasms/ethnology-
dc.subject.keywordChoroid Neoplasms/therapy-
dc.subject.keywordCombined Modality Therapy-
dc.subject.keywordDisease-Free Survival-
dc.subject.keywordEye Enucleation-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordHyperthermia, Induced*-
dc.subject.keywordMale-
dc.subject.keywordMelanoma/diagnosis*-
dc.subject.keywordMelanoma/ethnology-
dc.subject.keywordMelanoma/therapy-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNeoplasm Metastasis-
dc.subject.keywordPrognosis-
dc.subject.keywordRadiosurgery-
dc.subject.keywordRepublic of Korea/epidemiology-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordRuthenium Radioisotopes/therapeutic use*-
dc.subject.keywordTreatment Outcome-
dc.subject.keywordYoung Adult-
dc.contributor.alternativeNameKwon, Hee Jung-
dc.contributor.alternativeNameKim, Min-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.alternativeNameLee, Seung Kyu-
dc.contributor.affiliatedAuthorKwon, Hee Jung-
dc.contributor.affiliatedAuthorKim, Min-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.contributor.affiliatedAuthorLee, Seung Kyu-
dc.rights.accessRightsnot free-
dc.citation.volume97-
dc.citation.number5-
dc.citation.startPage653-
dc.citation.endPage658-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF OPHTHALMOLOGY, Vol.97(5) : 653-658, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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