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Elevated levels of preoperative CA 15-3 and CEA serum levels have independently poor prognostic significance in breast cancer

Authors
 J. S. Lee  ;  S. Park  ;  J. M. Park  ;  J. H. Cho  ;  S. I. Kim  ;  B.-W. Park 
Citation
 Annals of Oncology, Vol.24(5) : 1225-1231, 2013 
Journal Title
 Annals of Oncology 
ISSN
 0923-7534 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Breast Neoplasms/blood* ; Breast Neoplasms/mortality ; Breast Neoplasms/surgery ; Carcinoembryonic Antigen/blood* ; Female ; Humans ; Middle Aged ; Mucin-1/blood* ; Preoperative Period ; Prognosis ; Treatment Outcome ; Young Adult
Keywords
breast cancer ; CA 15-3 ; CEA ; prognostic factor ; tumor marker
Abstract
BACKGROUND: To evaluate the prognostic value of preoperative tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA), in breast cancers. PATIENTS AND METHODS: Preoperative CA 15-3 and CEA levels of 1681 patients were measured. The association of both tumor markers levels with clinicopathological parameters and outcomes was investigated by univariate and multivariate analyses. RESULTS: Among 1681 patients, elevated preoperative CA15-3 and CEA levels were identified in 176 and 131 patients, respectively. Higher preoperative CA 15-3 and CEA levels were significantly associated with a larger tumor size, axillary node metastases, and advanced stage. Patients with elevated CA 15-3 and CEA levels showed worse survival, even in stage-matched analysis. Patients with normal levels of both CA15-3 and CEA showed better survival than those with one or both markers levels elevated. In multivariate analysis, elevated preoperative CA 15-3 and CEA levels were independent prognostic factors. The statistical significance of elevated preoperative tumor markers levels on survival was solidified with longer follow-up and larger study population. CONCLUSIONS: Elevated preoperative CA 15-3 and CEA levels are associated with tumor burden and showed independent prognostic significance. Therefore, new treatment strategies are necessary for patients with elevated preoperative CA 15-3 and CEA levels in clinical practice.
Files in This Item:
T201302340.pdf Download
DOI
10.1093/annonc/mds604
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Ji Min(박지민)
Lee, Jun Sang(이준상) ORCID logo https://orcid.org/0000-0002-4054-6900
Cho, Jung Hoon(조정훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87284
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