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Kisspeptin, Leptin, and Retinol-Binding Protein 4 in Women with Polycystic Ovary Syndrome

Authors
 Jeon Y.E.  ;  Lee K.E.  ;  Jung J.A.  ;  Yim S.Y.  ;  Kim H.  ;  Seo S.K.  ;  Cho S.  ;  Choi Y.S.  ;  Lee B.S. 
Citation
 GYNECOLOGIC AND OBSTETRIC INVESTIGATION, Vol.75(4) : 268-274, 2013 
Journal Title
 GYNECOLOGIC AND OBSTETRIC INVESTIGATION 
ISSN
 0378-7346 
Issue Date
2013
MeSH
Adolescent ; Adult ; Blood Glucose/metabolism ; Body Mass Index ; Female ; Gonadal Steroid Hormones/blood ; Humans ; Insulin/blood ; Kisspeptins/blood* ; Leptin/blood* ; Obesity/complications ; Obesity/metabolism* ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/metabolism* ; Retinol-Binding Proteins, Plasma/metabolism* ; Young Adult
Keywords
Polycystic ovary syndrome ; Kisspeptin ; Leptin ; Retinol-binding protein 4 ; Insulin resistance
Abstract
OBJECTIVES: To compare plasma kisspeptin, serum leptin, and serum retinol-binding protein 4 (RBP4) levels in women with and without polycystic ovary syndrome (PCOS) and to correlate these among each other and with clinical, hormonal, and metabolic parameters. METHODS: Ninety women, including 54 women with PCOS and 36 without PCOS, participated in this study. For all patients, history and physical examinations were performed and blood samples were collected between days 3 and 8 of a spontaneous bleeding episode in the PCOS group and during normal menses of controls. Plasma kisspeptin, serum leptin, and serum RBP4 levels were measured using specific commercial assays. RESULTS: Kisspeptin, leptin, and RBP4 levels were significantly higher in the PCOS group than in controls. Kisspeptin and RBP4 levels were significantly higher among obese PCOS patients than controls. Leptin levels were higher among obese PCOS patients than non-obese PCOS patients or controls. Kisspeptin and leptin levels of PCOS patients were significantly correlated with RBP4 levels. When only obese PCOS patients were analyzed, kisspeptin levels correlated with only the free androgen index. CONCLUSIONS: These findings suggest that kisspeptin, leptin, and RBP4 are associated with metabolic disturbances in women with PCOS.
Full Text
http://www.karger.com/Article/FullText/350217
DOI
10.1159/000350217
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Lee, Kyung Eun(이경은)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Jeon, Young Eun(전영은)
Jung, Ji Ann(정지안)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87201
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