3 310

Cited 43 times in

Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism

DC FieldValueLanguage
dc.contributor.author구향모-
dc.contributor.author김찬호-
dc.contributor.author김형래-
dc.contributor.author도화미-
dc.contributor.author박정탁-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author이혜선-
dc.contributor.author한승혁-
dc.contributor.author한재현-
dc.contributor.author강신욱-
dc.contributor.author고광일-
dc.date.accessioned2014-12-18T08:55:13Z-
dc.date.available2014-12-18T08:55:13Z-
dc.date.issued2013-
dc.identifier.issn1050-7256-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87195-
dc.description.abstractBackground: Subclinical hypothyroidism (SCH) is not a rare condition in females, the elderly, or patients with chronic kidney disease (CKD). Even though previous studies have demonstrated that thyroid hormone replacement therapy (THRT) improves cardiac function and dyslipidemia in patients with SCH, it remains unclear as to whether THRT can improve renal function in CKD patients with SCH. This study investigated the impact of THRT on changes in estimated glomerular filtration rates (eGFR) in this patient population. Methods: A total of 113 CKD patients with SCH who were treated with L-thyroxine and had eGFR available for at least 24 months before and after THRT were enrolled between January 2005 and December 2011. A linear mixed model was used to compare patients' clinical and biochemical parameters at various time points. The slope of the decline in eGFR over time, both before and after THRT, was also calculated and compared using a linear mixed model. Results: The mean age of the study participants was 63.2±12.7 years, and 36 patients (31.9%) were men. The mean follow-up duration before and after THRT was 28.6±4.5 and 30.6±6.4 months respectively. After 24 months of THRT, serum thyrotropin (TSH) levels were significantly reduced—8.86±0.49 versus 1.41±0.73 μIU/mL, p<0.001—but there were no significant changes in triiodothyronine and free thyroxine concentrations. Serum albumin, calcium, phosphate, cholesterol, and triglyceride levels were also comparable before and after THRT. The rates of decline in eGFR were significantly attenuated by THRT (−4.31±0.51 vs.−1.08±0.36 [mL/min]/[year·1.73 m2], p<0.001), even after adjustment for age, sex, diabetes, mean arterial pressure, and serum albumin, cholesterol, and triglyceride concentrations (p<0.001). Conclusion: THRT attenuated the rate of decline in renal function in CKD patients with SCH, suggesting that THRT may delay reaching end-stage renal disease in these patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfThyroid-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHDisease Progression-
dc.subject.MESHDown-Regulation/drug effects-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlomerular Filtration Rate/drug effects-
dc.subject.MESHHormone Replacement Therapy*-
dc.subject.MESHHumans-
dc.subject.MESHHypothyroidism/blood-
dc.subject.MESHHypothyroidism/complications-
dc.subject.MESHHypothyroidism/drug therapy*-
dc.subject.MESHHypothyroidism/physiopathology-
dc.subject.MESHKidney/drug effects*-
dc.subject.MESHKidney/physiopathology-
dc.subject.MESHKidney Failure, Chronic/etiology-
dc.subject.MESHKidney Failure, Chronic/prevention & control-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMedical Records-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRenal Insufficiency, Chronic/blood-
dc.subject.MESHRenal Insufficiency, Chronic/complications-
dc.subject.MESHRenal Insufficiency, Chronic/drug therapy*-
dc.subject.MESHRenal Insufficiency, Chronic/physiopathology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHThyrotropin/blood-
dc.subject.MESHThyroxine/therapeutic use*-
dc.titleThyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorKwang Il Ko-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorHyoung Rae Kim-
dc.contributor.googleauthorJae Hyun Han-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1089/thy.2012.0475-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00203-
dc.contributor.localIdA01037-
dc.contributor.localIdA01147-
dc.contributor.localIdA01315-
dc.contributor.localIdA01654-
dc.contributor.localIdA02097-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA04304-
dc.contributor.localIdA04320-
dc.contributor.localIdA00053-
dc.contributor.localIdA00110-
dc.contributor.localIdA03312-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02729-
dc.identifier.pmid23281965-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/thy.2012.0475-
dc.subject.keywordAged-
dc.subject.keywordDisease Progression-
dc.subject.keywordDown-Regulation/drug effects-
dc.subject.keywordFemale-
dc.subject.keywordFollow-Up Studies-
dc.subject.keywordGlomerular Filtration Rate/drug effects-
dc.subject.keywordHormone Replacement Therapy*-
dc.subject.keywordHumans-
dc.subject.keywordHypothyroidism/blood-
dc.subject.keywordHypothyroidism/complications-
dc.subject.keywordHypothyroidism/drug therapy*-
dc.subject.keywordHypothyroidism/physiopathology-
dc.subject.keywordKidney/drug effects*-
dc.subject.keywordKidney/physiopathology-
dc.subject.keywordKidney Failure, Chronic/etiology-
dc.subject.keywordKidney Failure, Chronic/prevention & control-
dc.subject.keywordLinear Models-
dc.subject.keywordMale-
dc.subject.keywordMedical Records-
dc.subject.keywordMiddle Aged-
dc.subject.keywordRenal Insufficiency, Chronic/blood-
dc.subject.keywordRenal Insufficiency, Chronic/complications-
dc.subject.keywordRenal Insufficiency, Chronic/drug therapy*-
dc.subject.keywordRenal Insufficiency, Chronic/physiopathology-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordSeverity of Illness Index-
dc.subject.keywordThyrotropin/blood-
dc.subject.keywordThyroxine/therapeutic use*-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameKim, Hyoung Rae-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKo, Kwang Il-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorKim, Hyoung Rae-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKo, Kwang Il-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.rights.accessRightsnot free-
dc.citation.volume23-
dc.citation.number6-
dc.citation.startPage654-
dc.citation.endPage661-
dc.identifier.bibliographicCitationThyroid, Vol.23(6) : 654-661, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.