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Mucosal mast cell count is associated with intestinal permeability in patients with diarrhea predominant irritable bowel syndrome

Authors
 Hyuk Lee ; Jung Ho Park ; Seoung Wan Chae ; Byung Ik Kim ; Woo Kyu Jeon ; Chong Il Sohn ; Yong Kyun Cho ; Hong Joo Kim ; Dong Il Park 
Citation
 Journal of Neurogastroenterology and Motility, Vol.19(2) : 244~250, 2013 
Journal Title
 Journal of Neurogastroenterology and Motility 
ISSN
 2093-0879 
Issue Date
2013
Abstract
Background/Aims Although mucosal mast cell tryptase is known to significantly increase intestinal permeability, the relationship between mucosal mast cells and intestinal permeability remains unclear. The objective of this study was to evaluate the correlation among intestinal permeability, tryptase activity and mucosal mast cell count. Methods Rectal biopsies from 16 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and 7 normal subjects were assessed for tryptase activity and macromolecular permeability using horseradish peroxidase in Ussing chambers. In addition, mucosal mast cell levels were immunohistochemically quantified via image analysis. Results Rectal biopsy of tissues from IBS-D patients showed significantly increased permeability compared with those from normal controls (0.644 ± 0.08 and 0.06 ± 0.00 ng/2 hr/mm, < 0.01). Tryptase activity was also substantially higher in rectal biopsy samples from IBS-D patients than those from normal controls (0.86 ± 0.18 and 0.28 ± 0.04 mU/mg protein, < 0.05). Mucosal mast cell counts were not significantly different between the 2 groups ( > 0.05). However, correlation analysis revealed that only mucosal mast cell count was significantly correlated with intestinal permeability in IBS-D patients ( = 0.558, < 0.05). Conclusions This study demonstrated a positive correlation between the number of mucosal mast cells and intestinal permeability, suggesting that mucosal mast cells play an important role for increased intestinal permeability in patients with IBS-D.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87175
DOI
10.5056/jnm.2013.19.2.244
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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