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Transition zone defect associated with the response to proton pump inhibitor treatment in patients with globus sensation

Authors
 Min Seok Han  ;  Hyuk Lee  ;  Jung Hyun Jo  ;  In Rae Cho  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee 
Citation
 Journal of Gastroenterology and Hepatology, Vol.28(6) : 954-962, 2013 
Journal Title
 Journal of Gastroenterology and Hepatology 
ISSN
 0815-9319 
Issue Date
2013
MeSH
Deglutition Disorders/physiopathology* ; Female ; Humans ; Male ; Manometry* ; Middle Aged ; Proton Pump Inhibitors/therapeutic use* ; Sensation
Keywords
Deglutition Disorders/physiopathology* ; Female ; Humans ; Male ; Manometry* ; Middle Aged ; Proton Pump Inhibitors/therapeutic use* ; Sensation
Abstract
BACKGROUND AND AIM: Few data describing short-term proton pump inhibitor (PPI) treatment in patients with globus sensation exist. The aim of this study was to evaluate the use of high-resolution manometry (HRM) for predicting the response to PPI treatment in patients with globus sensation. METHOD: A total of 41 patients with globus sensation were treated with PPIs for 4 weeks and were classified as positive and negative responders. HRM topographical plots were analyzed for relevant manometric parameters. In addition, clinical and HRM data of 20 patients with typical gastroesophageal reflux disease (GERD) not presenting globus symptom were analyzed. RESULTS: Of the 41 patients, 19 (46%) were clinically diagnosed with GERD. The proportion of patients with favorable symptomatic improvement was higher in patients with GERD than in those without reflux (P=0.046). Positive and negative responders to PPI treatment did not differ in upper esophageal sphincter and proximal esophageal contraction. In globus patients with GERD, the temporal and spatial dimension of the transitional zone were greater among negative responders than among PPI-positive responders (P=0.010 and P=0.011). Regarding GERD patients without globus, there was no significant difference in transition zone defect according to PPI responsiveness. By receiver operating characteristic curve analysis, 2.1 cm and 1.1 s were found to be the spatial and temporal transitional zone dimensions that best differentiated positive and negative responders. CONCLUSION: In patients with GERD-related globus, there were larger transition zone defect in the negative responders compared with the PPI-positive responders.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jgh.12136/abstract
DOI
10.1111/jgh.12136
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
Cho, In Rae(조인래)
Jo, Jung Hyun(조중현) ORCID logo https://orcid.org/0000-0002-2641-8873
Han, Min Seok(한민석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87174
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