Cited 14 times in
The role of thioredoxin 1 in the mycophenolic acid-induced apoptosis of insulin-producing cells
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 도지혜 | - |
dc.contributor.author | 박윤준 | - |
dc.contributor.author | 조유리 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 김명수 | - |
dc.date.accessioned | 2014-12-18T08:53:06Z | - |
dc.date.available | 2014-12-18T08:53:06Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87129 | - |
dc.description.abstract | Mycophenolic acid (MPA) is one of many effective immunosuppressive drugs. However, MPA can induce cellular toxicity and impair cellular function in β-cells. To explore the effects of MPA and the relation between MPA and Trx-1, we used various methods, including an Illumina microarray, to identify the genes regulated during pancreatic β-cell death following MPA treatment. INS-1E cells (a pancreatic β-cell line) and isolated rat islets were treated with MPA for 12, 24, or 36 h, and subsequent microarray analysis showed that (Trx1) gene expression was significantly reduced by MPA. Further, Trx1 overexpression increased the cell viability, decreased the activations of c-jun N-terminal kinase (JNK) and caspase-3 by MPA, and attenuated ROS upregulation by MPA. Furthermore, siRNA knockdown of Trx1 increased MPA-induced cell death and the activations of p-JNK and caspase-3, and MPA significantly provoked the apoptosis of insulin-secreting cells via Trx1 downregulation. Our findings suggest that the prevention of Trx1 downregulation in response to MPA is critical for successful islet transplantation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CELL DEATH & DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Immunosuppressive Agents/pharmacology* | - |
dc.subject.MESH | Insulin-Secreting Cells/drug effects | - |
dc.subject.MESH | Insulin-Secreting Cells/physiology* | - |
dc.subject.MESH | Islets of Langerhans Transplantation | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/genetics | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | Mycophenolic Acid/pharmacology* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Primary Cell Culture | - |
dc.subject.MESH | Rats, Inbred Lew | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Thioredoxins/genetics* | - |
dc.subject.MESH | Thioredoxins/metabolism | - |
dc.subject.MESH | Thioredoxins/physiology | - |
dc.subject.MESH | Transcriptome/drug effects | - |
dc.title | The role of thioredoxin 1 in the mycophenolic acid-induced apoptosis of insulin-producing cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | KH Huh | - |
dc.contributor.googleauthor | Y Cho | - |
dc.contributor.googleauthor | BS Kim | - |
dc.contributor.googleauthor | JH Do | - |
dc.contributor.googleauthor | Y-J Park | - |
dc.contributor.googleauthor | DJ Joo | - |
dc.contributor.googleauthor | MS Kim | - |
dc.contributor.googleauthor | YS Kim | - |
dc.identifier.doi | 10.1038/cddis.2013.247 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01314 | - |
dc.contributor.localId | A01604 | - |
dc.contributor.localId | A03872 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J00482 | - |
dc.identifier.eissn | 2041-4889 | - |
dc.identifier.pmid | 23846223 | - |
dc.subject.keyword | Immunosuppressive Agents/pharmacology* | - |
dc.subject.keyword | Insulin-Secreting Cells/drug effects | - |
dc.subject.keyword | Insulin-Secreting Cells/physiology* | - |
dc.subject.keyword | Islets of Langerhans Transplantation | - |
dc.subject.keyword | MAP Kinase Signaling System | - |
dc.subject.keyword | Mitogen-Activated Protein Kinases/genetics | - |
dc.subject.keyword | Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.keyword | Mycophenolic Acid/pharmacology* | - |
dc.subject.keyword | Oligonucleotide Array Sequence Analysis | - |
dc.subject.keyword | Primary Cell Culture | - |
dc.subject.keyword | Rats, Inbred Lew | - |
dc.subject.keyword | Reactive Oxygen Species/metabolism | - |
dc.subject.keyword | Thioredoxins/genetics* | - |
dc.subject.keyword | Thioredoxins/metabolism | - |
dc.subject.keyword | Thioredoxins/physiology | - |
dc.subject.keyword | Transcriptome/drug effects | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Do, Ji Hye | - |
dc.contributor.alternativeName | Park, Youn Joon | - |
dc.contributor.alternativeName | Cho, Yu Ri | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Do, Ji Hye | - |
dc.contributor.affiliatedAuthor | Park, Youn Joon | - |
dc.contributor.affiliatedAuthor | Cho, Yu Ri | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 4 | - |
dc.citation.startPage | 721 | - |
dc.identifier.bibliographicCitation | CELL DEATH & DISEASE, Vol.4 : 721, 2013 | - |
dc.identifier.rimsid | 32508 | - |
dc.type.rims | ART | - |
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