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Serum carcinoembryonic antigen is associated with non-alcoholic fatty liver disease in healthy Korean non-smokers

Authors
 Jee-Yon Lee  ;  Duk-Chul Lee  ;  Ji-Won Lee 
Citation
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol.51(7) : 1499-1504, 2013 
Journal Title
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE 
ISSN
 1434-6621 
Issue Date
2013
MeSH
Adult ; Asian Continental Ancestry Group ; Aspartate Aminotransferases/blood ; Blood Glucose/analysis ; Blood Pressure ; Carcinoembryonic Antigen/blood* ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Fatty Liver/blood* ; Fatty Liver/diagnosis ; Fatty Liver/ethnology ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Non-alcoholic Fatty Liver Disease ; Risk Factors ; Triglycerides/blood ; gamma-Glutamyltransferase/blood
Keywords
carcinoembryonic antigen (CEA) ; inflammation ; non-alcoholic fatty liver disease
Abstract
BACKGROUND: Carcinoembryonic antigen (CEA), a biomarker overexpressed in malignant tumors, exhibits increased levels in certain non-malignant conditions, including chronic inflammatory status. The elevation of CEA in chronic inflammatory conditions suggests that this marker may also be associated with non-alcoholic fatty liver disease (NAFLD). Therefore, we investigated the relationship between serum CEA concentrations and NAFLD in healthy Korean non-smokers. METHODS: A total of 200 healthy Korean non-smokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with the presence of NAFLD using the liver Fibroscan®. Serum CEA levels were measured using a chemiluminescence immunoassay analyzer. RESULTS: The prevalence of NAFLD increased significantly with increasing CEA quartiles; the mean log CEA level increased gradually according to the grade of hepatic steatosis. Multivariate logistic regression analysis adjusted for age, gender, body mass index, exercise, blood pressure, fasting glucose, insulin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, white blood cell counts, aspartate aminotransferase, alanine aminotransferase and γ-glutamyltransferase showed that the fourth CEA quartile was associated with NAFLD, with an odds ratio of 2.98 (95% confidence interval 1.10-8.05, p<0.01). CONCLUSIONS: Our study showed independent associations between CEA and NAFLD by analyzing data from 200 healthy Korean non-smokers, suggesting that CEA functions in the pathophysiology of fatty liver disease. Further studies are required to better understand the clinical and pathophysiological significance of our findings.
Full Text
http://www.degruyter.com/view/j/cclm.2013.51.issue-7/cclm-2012-0585/cclm-2012-0585.xml
DOI
10.1515/cclm-2012-0585
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87045
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